Document Detail


Free fatty acid analysis in ascitic fluid improves diagnosis in malignant abdominal tumors.
MedLine Citation:
PMID:  7586583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fasting concentration of free fatty acids (FFA) in the ascitic fluid was determined in 14 patients with malignant ascites and in 19 patients with liver cirrhosis. In malignant ascites FFA levels were increased more than three times when compared with the levels in cirrhotic ascites (5.241 +/- 0.493 vs. 1.558 +/- 0.170 mumol/ml; P < 0.0001). Palmitic acid was the most representative saturated FFA (which together accounted for 2.499 +/- 0.323 vs. 0.833 +/- 0.064 mumol/ml; P < 0.0001), while unsaturated FFA (2.741 +/- 0.298 vs. 0.725 +/- 0.111 mumol/ml; P < 0.001) were represented, in decreasing order, by oleic, linoleic and arachidonic acids. The ratio of unsaturated to saturated FFA was higher in neoplastic patients (1.35 +/- 0.29 vs. 0.826 +/- 0.065 P < 0.05). Albumin concentration in ascitic fluid of neoplastic patients was 22.44 +/- 1.35 g/l, while that of cirrhotic patients was 8.19 +/- 0.32 g/l, P < 0.0001. A close relationship (R2 = 95.14%) between albumin concentration in ascitic fluid and levels of total FFA was found. These data support the hypothesis that the elevation of FFA in ascitic fluid allows discrimination between malignant and non-malignant ascites.
Authors:
A V Greco; G Mingrone; G Gasbarrini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  239     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-12-21     Completed Date:  1995-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  13-22     Citation Subset:  IM    
Affiliation:
Institute of Internal Medicine, Catholic University, Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Albumins / analysis
Arachidonic Acid / analysis
Ascitic Fluid / chemistry*
Carcinoma, Hepatocellular / chemistry*,  diagnosis
Fatty Acids, Nonesterified / analysis*
Female
Humans
Linoleic Acid
Linoleic Acids / analysis
Liver Cirrhosis / metabolism
Liver Neoplasms / chemistry*,  diagnosis
Male
Middle Aged
Oleic Acid
Oleic Acids / analysis
Palmitic Acid
Palmitic Acids / analysis
Peritoneal Neoplasms / chemistry,  diagnosis
Chemical
Reg. No./Substance:
0/Albumins; 0/Fatty Acids, Nonesterified; 0/Linoleic Acids; 0/Oleic Acids; 0/Palmitic Acids; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid; 57-10-3/Palmitic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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