Document Detail

Free amino acids in motor cortex of amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  421837     Owner:  NLM     Status:  MEDLINE    
Free amino acids were estimated quantitatively in the motor cortex from 3 patients with amyotrophic lateral sclerosis (ALS) and 11 control subjects. Among 7 amino acids which showed statistically significant changes, taurine was the only one which was increased constantly and most markedly in the motor cortex of all the 3 ALS cases. It was suggested that the metabolism of sulfur amino acids might be affected in comparatively early stages of ALS.
Y Yoshino; H Koike; K Akai
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experientia     Volume:  35     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  219-20     Citation Subset:  IM    
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MeSH Terms
Amino Acids / metabolism*
Amyotrophic Lateral Sclerosis / metabolism*
Middle Aged
Motor Cortex / cytology,  metabolism*
Taurine / metabolism
Reg. No./Substance:
0/Amino Acids; 107-35-7/Taurine

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