Document Detail

Free IGF-I, IGFBP-1, and the binary complex of IGFBP-1 and IGF-I are increased during human pregnancy.
MedLine Citation:
PMID:  15467298     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To investigate changes in free insulin-like growth factor I (IGF-I) and IGF-binding protein 1 (IGFBP-1) complexed IGF-I during human pregnancy. METHODS: Overnight fasting serum was obtained in a longitudinal design from 11 women with non-complicated pregnancy at gestation weeks 6-10, 16-20, 24-28 and 35-38 and, for comparison, 5 weeks post-partum. All samples were analyzed for total and free IGF-I and IGF-II, IGFBP-3 and IGFBP-3 proteolysis, total and non-phosphorylated (np-) IGFBP-1, and IGFBP-1 complexed IGF-I. RESULTS: Total IGF-I was increased in late pregnancy (week 35-38) (p < 0.001), whereas free IGF-I was significantly increased by 77% already at week 6-10 (p = 0.004) and by 140% (p = 0.002) at week 34-38, when compared to post-partum levels. At weeks 16-20 and 24-28, levels of free IGF-I were not significantly different from post-partum levels. Significant IGFBP-3 proteolysis was detectable from week 6-10 and throughout pregnancy (p < 0.05). Total and np-IGFBP-1 were significantly increased from 16-20 weeks of pregnancy (both p < 0.05) and IGFBP-1 complexed IGF-I was increased 2-fold from week 16-20 and throughout pregnancy (p < 0.05). However, the saturation of IGFBP-1 remained constant at 27-29% during the study. CONCLUSION: We found evidence of increased free IGF-I and increased IGF-I in binary complexes during pregnancy, possibly caused by IGFBP-3 proteolysis and decreased ternary complex formation.
Christian Skjaerbaek; Jan Frystyk; Hans Orskov; Allan Flyvbjerg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-10-01
Journal Detail:
Title:  Hormone research     Volume:  62     ISSN:  0301-0163     ISO Abbreviation:  Horm. Res.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366126     Medline TA:  Horm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  215-20     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 S. Karger AG, Basel.
Medical Research Laboratories, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark.
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MeSH Terms
Case-Control Studies
Insulin-Like Growth Factor Binding Protein 1
Insulin-Like Growth Factor Binding Proteins / blood*,  chemistry
Insulin-Like Growth Factor I / chemistry,  metabolism*
Multiprotein Complexes
Pregnancy / blood*
Pregnancy Proteins / blood*,  chemistry
Time Factors
Reg. No./Substance:
0/IGFBP1 protein, human; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Proteins; 0/Multiprotein Complexes; 0/Pregnancy Proteins; 67763-96-6/Insulin-Like Growth Factor I

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