Document Detail


Free D-aspartate in mammals.
MedLine Citation:
PMID:  16141517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
D-Aspartate (D-Asp) is an endogenous amino acid present in nervous and endocrine tissues in mammals. A high concentration of D-Asp is observed in embryos, which disappears in nervous tissues after delivery, but increases temporarily in endocrine glands, particularly in the pituitary, pineal and adrenal glands at the specific stages. In the pineal gland, D-Asp that is apparently derived from other tissues suppresses melatonin secretion from parenchymal cells. Additionally, D-Asp levels increase in the testis just before birth and during maturation. The amino acid is presumed to be synthesized by the pituitary gland and testis. In the testis, D-Asp produced inside the seminiferous tubules acts on Leydig cells following release to enhance testosterone synthesis by activating the expression of Steroidogenic Acute Regulatory protein. Mammalian cells appear to contain all the molecular components required to regulate D-Asp homeostasis, as they can synthesize, release, take up, and degrade the amino acid. These findings collectively indicate that D-Asp is a novel type of messenger in the mammalian body.
Authors:
Takemitsu Furuchi; Hiroshi Homma
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  28     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1566-70     Citation Subset:  IM    
Affiliation:
Laboratory of Biomolecular Science, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspartic Acid / analysis,  biosynthesis,  metabolism,  physiology*
Humans
Mammals / physiology*
Chemical
Reg. No./Substance:
56-84-8/Aspartic Acid

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