Document Detail


Free D-amino acids in human cerebrospinal fluid of Alzheimer disease, multiple sclerosis, and healthy control subjects.
MedLine Citation:
PMID:  7702702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This is the first report of the presence of free D-amino acids in lumbar and ventricular human cerebrospinal fluid (CSF) of individuals with Alzheimer disease (AD) compared with CSF of normal control subjects and with individuals affected by multiple sclerosis, as an unrelated neurologic disorder. Free D-amino acids are present at significantly higher levels in AD CSF than normal CSF, whereas in the CSF of patients affected by multiple sclerosis, D-amino acids occurs at the same level as in the normal controls. The total D-amino acid content in ventricular CSF was 1.48 times higher in the AD than controls (26.4 vs 17.9 nmol/mL, p = 0.025). The total D-amino acid content was 1.43 times higher in AD lumbar CSF than controls (1.89 vs 1.32 nmol/mL, p = 0.001). D-Aspartate in particular was 2.74 times higher in AD ventricular CSF compared to normal ventricular CSF (3.34 vs 1.22 nmol/mL, p = 0.029). In lumbar CSF, D-aspartate was 1.5 times higher in AD than controls (0.054 vs 0.036 nmol/mL, p = 0.041). Previously we reported that D-amino acids are elevated in AD brain proteins associated with neurofibrillary tangles compared to normal brain proteins (D'Aniello et al., 1992c; Fisher et al., 1992a,b). Thus, the D-amino acids present in CSF may originate from degradation of brain proteins.
Authors:
G H Fisher; L Petrucelli; C Gardner; C Emory; W H Frey; L Amaducci; S Sorbi; G Sorrentino; M Borghi; A D'Aniello
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid     Volume:  23     ISSN:  1044-7393     ISO Abbreviation:  Mol. Chem. Neuropathol.     Publication Date:    1994 Oct-Dec
Date Detail:
Created Date:  1995-05-08     Completed Date:  1995-05-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8910358     Medline TA:  Mol Chem Neuropathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-24     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Barry University, Miami Shores, FL 33161.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / cerebrospinal fluid*
Amino Acids / cerebrospinal fluid*
Humans
Multiple Sclerosis / cerebrospinal fluid*
Reference Values
Stereoisomerism
Grant Support
ID/Acronym/Agency:
S06 GM45455/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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