| Franz Volhard lecture. Increased systemic vascular resistance and primary hypertension: the expanding complexity. | |
| | |
MedLine Citation:
|
PMID: 2095384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Polygenetic predisposition is a key factor in the multifactorial disorders of primary hypertension. It is suggested that endothelial cell abnormalities are the major factors responsible for the increase in total systemic vascular resistance that leads to an elevation in arterial blood pressure. Thus, resetting of the arterial baroreceptors could be a consequence of endothelial-mediated changes in mechano-electrical transduction in the arterial mechanoreceptors. In consequence, inhibition of the vasomotor centers would be diminished and the resulting neurohumoral excitation would constrict the systemic resistance blood vessels. Later, as left ventricular hypertrophy develops, the inhibitory input of the cardiac mechanoreceptors is also reduced. In normal endothelial cells there is a predominant formation and release of vascular smooth muscle relaxing and growth-inhibiting factors. However, it is proposed that genetic changes lead to a predominate formation of endothelium-derived contracting factors and mitogens. The former would augment the neurohumoral vasoconstriction. The latter, aided by the increased arterial pressure and the augmented output of norepinephrine, would lead to structural alterations in the arterial vessels, thus reducing the lumen area, amplifying the vasoconstrictor response to contractile agents and limiting vasodilation. In this way the hypertension would be perpetuated. |
| | |
Authors:
|
J T Shepherd |
Related Documents
:
|
2189444 - Imbalance of endothelium-derived relaxing and contracting factors. a new concept in hyp... 8185714 - Nitrogen monoxide transport mechanisms. 16512874 - Cholinergic control of epidermal cohesion. 11302774 - Prolonged effects of acute gamma irradiation on acetylcholine-induced potassium current... 17511624 - Modulation of the effects of chylomicron remnants on endothelial function by minor diet... 7211274 - Thymidine incorporation by human corneal endothelium during organ culture. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 8 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1990 Dec |
Date Detail:
|
Created Date: 1991-07-08 Completed Date: 1991-07-08 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: S15-27 Citation Subset: IM; S |
Affiliation:
|
Mayo Clinic and Foundation, Rochester, Minnesota 55905. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Endothelium, Vascular / physiology Growth Substances / physiology Humans Hypertension / genetics, physiopathology* Mechanoreceptors / physiology Nitric Oxide / physiology Pressoreceptors / physiology Reflex / physiology Sympathetic Nervous System / physiology Vascular Resistance / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Growth Substances; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Various approaches to blockade of the renin-angiotensin system: persistent renin response.
Next Document: Parathyroid hypertensive factor.