Document Detail

Franz Volhard and Theodor Fahr: achievements and controversies in their research in renal disease and hypertension.
MedLine Citation:
PMID:  11223997     Owner:  NLM     Status:  MEDLINE    
The clinician, Franz Volhard, and the pathologist, Theodor Fahr, worked closely together in Mannheim from 1909 until 1915 and introduced a novel classification of renal diseases. In the monograph entitled 'Die Bright'sche Nierenkrankheit, Klinik, Pathologie und Atlas' (1914) they differentiated between degenerative (nephroses), inflammatory (nephritides) and arteriosclerotic (scleroses) diseases. Nephrosclerosis was divided into the benign and malignant form, of which the latter stood the test of time as a new disease entity. Fahr further divided benign nephrosclerosis into the compensated and decompensated form--depending on the presence or absence of glomerular injury. In the pathogenesis of malignant nephrosclerosis, Volhard stressed the decisive role of severe blood pressure elevation, while Fahr postulated an inflammatory mechanism, a concept later confirmed by Adalbert Bohle for at least a minority of patients. A very far reaching concept of Franz Volhard was his idea that pale (renal) hypertension results from a pressor substance released from ischaemic kidney(s) contributing--via a vicious circle--to a further rise in blood pressure with subsequent renovascular injury and aggravation of hypertension. This hypothesis was supported in 1930 by initial experiments of his collaborator, Hartwich (demonstrating in dogs a mild rise in blood pressure after ligation of branches of the renal artery) and definitively proven by Goldblatt (1934) in dogs by induction of severe and persistent hypertension after clamping of both renal arteries. The consequent detection of the renin angiotensin system was the final confirmation of Volhard's postulated renal pressor substance. In the pathogenesis of red (essential) hypertension, Volhard stressed the role of hereditary factors, age, obesity and potentially of severe alcoholism. He emphasised a premature reduction of vascular distensibility (due to elastosis of the prearterioles), a high cardiac output as well as a dampening of baroceptor function. Additionally, Volhard made crucial advances in cardiology and pneumology. Journal of Human Hypertension (2001) 15, 5-16
A Heidland; W Gerabek; K Sebekova
Related Documents :
11641307 - Impairment of renal vasodilation with l-arginine is related to more severe disease in u...
3259447 - Regional hemodynamic responses to central administration of corticotropin-releasing fac...
8743537 - Chronic effects of nitric oxide and prostaglandin inhibition on pressure diuresis and n...
6171687 - Systemic and renal hemodynamic effects of trimazosin: a new vasodilator.
19851697 - Clinical, manometric and profilometric evaluation after surgery for hirschsprung's dise...
6341217 - Increase in collateral arterial endothelial cell proliferation induced by captopril aft...
Publication Detail:
Type:  Biography; Historical Article; Journal Article; Portraits; Review    
Journal Detail:
Title:  Journal of human hypertension     Volume:  15     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-06     Completed Date:  2001-05-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  5-16     Citation Subset:  IM    
Department of Internal Medicine, University of Wuerzburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
History, 20th Century
Hypertension / history*
Kidney Diseases / history*
Personal Name Subject
Personal Name Subject:
F Volhard; T Fahr

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adenoviral vector design for high-level transgene expression in primitive human hematopoietic progen...
Next Document:  Why is plasma renin activity lower in populations of African origin?