Document Detail


Francisella tularensis replicates within alveolar type II epithelial cells in vitro and in vivo following inhalation.
MedLine Citation:
PMID:  17088343     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Francisella tularensis replicates in macrophages and dendritic cells, but interactions with other cell types have not been well described. F. tularensis LVS invaded and replicated within alveolar epithelial cell lines. Following intranasal inoculation of C57BL/6 mice, Francisella localized to the alveolus and replicated within alveolar type II epithelial cells.
Authors:
Joshua D Hall; Robin R Craven; James R Fuller; Raymond J Pickles; Thomas H Kawula
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-11-06
Journal Detail:
Title:  Infection and immunity     Volume:  75     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-03-08     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1034-9     Citation Subset:  IM    
Affiliation:
University of North Carolina, Chapel Hill, NC 27599-7290, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Colony Count, Microbial
Disease Models, Animal
Epithelial Cells / microbiology*
Francisella tularensis / growth & development*
Humans
Immunohistochemistry
Macrophages / microbiology
Mice
Mice, Inbred C57BL
Microscopy, Fluorescence
Pulmonary Alveoli / cytology*,  microbiology*
Tularemia / microbiology*
Grant Support
ID/Acronym/Agency:
R21-AI053399/AI/NIAID NIH HHS; U54-AI057157/AI/NIAID NIH HHS
Comments/Corrections

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