Document Detail


Framingham cardiovascular risk profile correlates with impaired hippocampal and cortical vasoreactivity to hypercapnia.
MedLine Citation:
PMID:  20842159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vascular risk factors affect cerebral blood flow (CBF) and cerebral vascular reactivity, contributing to cognitive decline. Hippocampus is vulnerable to both Alzheimer's disease (AD) pathology and ischemia; nonetheless, the information about the impact of vascular risk on hippocampal perfusion is minimal. Cognitively, healthy elderly (NL=18, 69.9±6.7 years) and subjects with mild cognitive impairment (MCI=15, 74.9±8.1 years) were evaluated for the Framingham cardiovascular risk profile (FCRP). All underwent structural imaging and resting CBF assessment with arterial spin labeling (ASL) at 3T magnetic resonance imaging (MRI). In 24 subjects (NL=17, MCI=7), CBF was measured after a carbon dioxide rebreathing challenge. Across all subjects, FCRP negatively correlated with hippocampal (ρ=-0.41, P=0.049) and global cortical (ρ=-0.46, P=0.02) vasoreactivity to hypercapnia (VR(h)). The FCRP-VR(h) relationships were most pronounced in the MCI group: hippocampus (ρ=-0.77, P=0.04); global cortex (ρ=-0.83, P=0.02). The FCRP did not correlate with either volume or resting CBF. The hippocampal VR(h) was lower in MCI than in NL subjects (Z=-2.0, P=0.047). This difference persisted after age and FCRP correction (F([3,20])=4.6, P=0.05). An elevated risk for vascular pathology is associated with a reduced response to hypercapnia in both hippocampal and cortical tissue. The VR(h) is more sensitive to vascular burden than either resting CBF or brain volume.
Authors:
Lidia Glodzik; Henry Rusinek; Miroslaw Brys; Wai H Tsui; Remigiusz Switalski; Lisa Mosconi; Rachel Mistur; Elizabeth Pirraglia; Susan de Santi; Yi Li; Alexander Goldowsky; Mony J de Leon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-15
Journal Detail:
Title:  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism     Volume:  31     ISSN:  1559-7016     ISO Abbreviation:  J. Cereb. Blood Flow Metab.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-03-17     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8112566     Medline TA:  J Cereb Blood Flow Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  671-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Algorithms
Atrophy
Calibration
Carbon Dioxide / blood,  pharmacology
Cardiovascular Diseases / epidemiology*
Cerebral Cortex / pathology*
Cerebrovascular Circulation / physiology*
Female
Hippocampus / pathology*
Humans
Hypercapnia / pathology*,  physiopathology
Image Processing, Computer-Assisted
Infarction, Middle Cerebral Artery / epidemiology,  pathology
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Perfusion Imaging
Risk Assessment
Grant Support
ID/Acronym/Agency:
AG022374/AG/NIA NIH HHS; AG08051/AG/NIA NIH HHS; AG12101/AG/NIA NIH HHS; P30 AG008051/AG/NIA NIH HHS; R01 AG012101/AG/NIA NIH HHS; R01 AG013616/AG/NIA NIH HHS; R01 AG022374/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
142M471B3J/Carbon Dioxide
Comments/Corrections

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