Document Detail


Framing postpartum hemorrhage as a consequence of human placental biology: an evolutionary and comparative perspective.
MedLine Citation:
PMID:  21909154     Owner:  HMD     Status:  MEDLINE    
Abstract/OtherAbstract:
Postpartum hemorrhage (PPH), the leading cause of maternal mortality worldwide, is responsible for 35 percent of maternal deaths. Proximately, PPH results from the failure of the placenta to separate from the uterine wall properly, most often because of impairment of uterine muscle contraction. Despite its prevalence and its well-described clinical manifestations, the ultimate causes of PPH are not known and have not been investigated through an evolutionary lens. We argue that vulnerability to PPH stems from the intensely invasive nature of human placentation. The human placenta causes uterine vessels to undergo transformation to provide the developing fetus with a high plane of maternal resources; the degree of this transformation in humans is extensive. We argue that the particularly invasive nature of the human placenta increases the possibility of increased blood loss at parturition. We review evidence suggesting PPH and other placental disorders represent an evolutionarily novel condition in hominins.
Authors:
Elizabeth T Abrams; Julienne N Rutherford
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Publication Detail:
Type:  Historical Article; Journal Article    
Journal Detail:
Title:  American anthropologist     Volume:  113     ISSN:  0002-7294     ISO Abbreviation:  Am Anthropol     Publication Date:  2011  
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-10-02     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  1275273     Medline TA:  Am Anthropol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  417-30     Citation Subset:  Q    
Affiliation:
University of Illinois, Chicago.
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MeSH Terms
Descriptor/Qualifier:
Biological Evolution
Embryo Implantation*
Female
History, 20th Century
History, 21st Century
Humans
Maternal Mortality* / ethnology,  history
Placentation*
Postpartum Hemorrhage* / ethnology,  history
Pregnancy
Trophoblasts*
Women's Health / ethnology,  history
Grant Support
ID/Acronym/Agency:
K12 HD055892/HD/NICHD NIH HHS; K12 HD055892-04/HD/NICHD NIH HHS
Comments/Corrections

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