Document Detail


Frameless stereotactic aspiration and subsequent fibrinolytic therapy for the treatment of spontaneous intracerebral haemorrhage.
MedLine Citation:
PMID:  20874455     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background and purpose. The options for managing spontaneous intracerebral haemorrhage (ICH) include conservative treatment, surgical removal of the haematoma and minimally invasive treatment with clot aspiration and subsequent fibrinolytic therapy. The discussion over which treatment is best for ICH remains controversial and management of patients with spontaneous ICH continues to be a challenge. The purpose of this study is to investigate the feasibility and safety of frameless stereotactic aspiration and subsequent fibrinolytic therapy for the treatment of spontaneous ICH. Methods. Patients with spontaneous supratentorial ICH were treated by a frameless stereotactic aspiration using the YL-1 type of intracranial haematoma puncture needle, followed by subsequent fibrinolytic therapy with urokinase. Results. Forty-eight patients were enrolled in the study. The median age was 65 years (range, 40-79). The median initial Glasgow Coma Scale (GCS) was 10 (range 6-14). The mean initial haematoma volume was 56.5 cm(3). Initial ICH volume was reduced by an average of 75% (range 50-90%). Ten patients (20.8%) died before hospital discharge. By the 3-month follow-up, another two patients had died, resulting in an overall mortality of 25.0%. For the primary end point, a good outcome (3-month GOS score >3) rate was noted in 41.7% of the patients. No intraoperative death was observed in this study. There were a total of 14 (29.2%) procedure-related complications, with an overall re-bleeding rate of 10.4%. Conclusions. Frameless stereotactic aspiration using the YL-1 type of intracranial haematoma puncture needle and subsequent fibrinolytic therapy for the treatment of spontaneous ICH is a simple and safe procedure with low re-bleeding rate and mortality.
Authors:
Xiaonan Chen; Wenya Chen; Aijin Ma; Xianghong Wu; Jiangang Zheng; Xiangrong Yu; Yi-Xiang J Wang; Daoyuan Wang
Related Documents :
15789525 - Preoperative versus postoperative radiation therapy for soft-tissue sarcomas.
12546345 - Intention-to-treat analysis of spetzler-martin grades iv and v arteriovenous malformati...
18639105 - Treatment selection for cerebral arteriovenous malformations: radiosurgery or microsurg...
17245625 - Peritumoral edema after stereotactic radiosurgery for intracranial meningiomas and mole...
2368435 - Clinical significance of associated nodular lesions of the adrenal in patients with ald...
22193885 - Clinical impact of extrapleural pneumonectomy for malignant pleural mesothelioma.
Publication Detail:
Type:  Journal Article     Date:  2010-09-28
Journal Detail:
Title:  British journal of neurosurgery     Volume:  25     ISSN:  1360-046X     ISO Abbreviation:  Br J Neurosurg     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800054     Medline TA:  Br J Neurosurg     Country:  England    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  IM    
Affiliation:
Department of Neurology, Wujin People's Hospital, affiliated to Jiangsu University, Changzhou, P. R. China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Optogenetics--shining light on neurosurgical conditions.
Next Document:  Endoscopic transsphenoidal approach to petrous apex cholesterol granulomas.