Document Detail

Fragrance contact dermatitis: a worldwide multicenter investigation (Part I).
MedLine Citation:
PMID:  8796746     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to determine the prevalence of responses to selected fragrance materials in patients with suspect fragrance allergy and to evaluate risk factors and associations with such responses. The validity of using specific fragrance ingredients versus a mixture of fragrances was evaluated in terms of predicting allergy to different fragrance ingredients. METHODS: One hundred sixty-seven subjects were evaluated in seven centers worldwide with a fragrance mix, the eight ingredients in the fragrance mixture, six other well-known fragrance allergens, balsam of Peru, and 15 lesser studied fragrance materials. RESULTS: The age of the patients was 44.9 +/- 17.5 years (mean +/- SD). More than 85% were women. A relatively high proportion gave a past history of atopic disease. Facial eruptions (40%) and hand involvement (26.7%) were the most common topographic sites. All but 4 of the 35 fragrance materials produced a positive response in > 1%. A reaction to fragrance mix occurred in 47.3%. Seven of the 34 ingredients tested produced an allergic response in more than 10% of those tested. Men were more likely than women to exhibit a positive response to five fragrance ingredients. White persons were more likely to react to perfume mix (52.8% versus 25.3%) and certain ingredients in the mix than Asian persons. Allergy to benzyl salicylate was more common in Japan than in Europe or the United States. CONCLUSION: The age at which patients with perfume allergy present for evaluation is similar to that of other contactants. Atopic individuals may be overrepresented in this group of patients. Face involvement is likely. White persons are more likely to react to fragrance mix, whereas in Asian patients benzyl salicylate was a more frequent allergen. Fragrance mix corrected with 85.6% of positive responses to fragrance ingredients. The addition of ylang ylang oil, narcissus oil, and sandalwood oil to fragrance mix would be expected to pick up 94.2% with positive responses to fragrance materials; adding balsam of Peru increases this to 96%.
W Larsen; H Nakayama; M Lindberg; T Fischer; P Elsner; D Burrows; W Jordan; S Shaw; J Wilkinson; J Marks; M Sugawara; J Nethercott
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society     Volume:  7     ISSN:  1046-199X     ISO Abbreviation:  Am. J. Contact Dermatitis     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-12-02     Completed Date:  1996-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100472     Medline TA:  Am J Contact Dermat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  77-83     Citation Subset:  IM    
Portland Dermatology Clinic, OR, USA.
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MeSH Terms
Age Distribution
Cosmetics / adverse effects
Dermatitis, Allergic Contact / epidemiology,  etiology*
Middle Aged
Patch Tests
Perfume / adverse effects*
Reproducibility of Results
Risk Factors
Sex Distribution
Reg. No./Substance:
0/Cosmetics; 0/Perfume

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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