Document Detail

Fragrance Material Review on 2-Hexylidene Cyclopentanone.
MedLine Citation:
PMID:  22450567     Owner:  NLM     Status:  Publisher    
A toxicologic and dermatologic review of 2-hexylidene cyclopentanone when used as a fragrance ingredient is presented. 2-Hexylidene cyclopentanone is a member of the fragrance structural group Ketones Alkyl Cyclic. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-hexylidene cyclopentanone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, and genotoxicity data. A safety assessment of the entire Ketones Alkyl Cyclic will be published simultaneously with this document; please refer to Belsito et al., 2011 (1) for an overall assessment of the safe use of this material and all Ketones Alkyl Cyclic in fragrances.
J Scognamiglio; L Jones; C S Letizia; A M Api
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-23
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Research Institute for Fragrance Materials, Inc. 50 Tice Boulevard, Woodcliff Lake, NJ 07677, U.S.A.
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