| Fragments of urinary fibrin/fibrinogen degradation products and cross-linked fibrin degradation products in various renal diseases. | |
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MedLine Citation:
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PMID: 2929008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In children with several kinds of glomerular disease, fragments of fibrin/fibrinogen degradation products (FDP) and cross-linked fibrin degradation products (XLFDP) in the urine were investigated by autoradiography using western blotting method. Results were compared with selectivity of proteins observed in cases of proteinuria, or with histological findings. Patients with nephrotic syndrome exhibited slightly increased amount of urinary FDP, consisted mainly of X and Y fragments. On the other hand, in cases of proliferative glomerulonephritis, such as acute glomerulonephritis, purpura nephritis, Ig A nephropathy, systemic lupus erythematosus, or hemolytic uremic syndrome, increased FDP, including XLFDP, was detected in the urine. In these cases, FDP was consisted mainly of fragments X, Y, and D-dimer, and could not be correlated with the degree of mesangial proliferation or with urinary protein selectivity. It was concluded that the increased urinary FDP and XLFDP were derived not only from filtration of plasma fibrinogen or FDP, but also from fibrinolysis of intraglomerular fibrin deposits. |
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Authors:
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K Taira; T Matsunaga; S Kawahara; S Sakamoto; H Kamitsuji |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Thrombosis research Volume: 53 ISSN: 0049-3848 ISO Abbreviation: Thromb. Res. Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-05-01 Completed Date: 1989-05-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0326377 Medline TA: Thromb Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 367-77 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nara Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Autoradiography Blotting, Western Child Cross-Linking Reagents* Fibrin Fibrinogen Degradation Products / urine* Glomerulonephritis / urine Glomerulonephritis, IGA / urine Glomerulonephritis, Membranous / urine Hemolytic-Uremic Syndrome / urine Humans Kidney Diseases / urine* Lupus Erythematosus, Systemic / urine Molecular Weight Nephrotic Syndrome / urine Purpura, Schoenlein-Henoch / urine |
| Chemical | |
Reg. No./Substance:
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0/Cross-Linking Reagents; 0/Fibrin Fibrinogen Degradation Products |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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