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Fragmented QRS Complexes Are Associated with Cardiac Fibrosis and Significant Intraventricular Systolic Dyssynchrony in Nonischemic Dilated Cardiomyopathy Patients with a Narrow QRS Interval.
MedLine Citation:
PMID:  20618390     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background: Myocardial scar causes heterogeneous ventricular activation, which results in fragmentation of QRS complexes on ECG. Myocardial fibrosis in patients with nonischemic cardiomyopathy (NDCM) can be identified as late gadolinium enhancement (LGE) areas on cardiac magnetic resonance (CMR) studies. We investigated the association of fragmented QRS (fQRS) complexes with systolic dyssynchrony and myocardial fibrosis in patients with NDCM. Methods: Twenty patients with NDCM and sinus rhythm who had fQRS complexes were evaluated with CMR. The association of fQRS complexes with LGE and systolic dyssynchrony was investigated. Results: Nineteen patients had significant systolic dyssynchrony with echocardiography. Among 19 patients with significant dyssynchrony, 14 (74%) patients had fQRS complexes in the most delayed contracting segment or one of the dyssynchronous segments, whereas five patients (26%) had fQRS complexes in a lead which is discordant with the dyssynchronous segment on echocardiography. Seventeen patients had LGE in their CMR. Among the 17 patients with LGE; 13 patients (76%) had fQRS complexes concordant with LGE present segments. Conclusion: Fragmentation of QRS complexes on ECG is associated with intraventricular systolic dyssynchrony and subendocardial fibrosis in NDCM patients with a narrow QRS interval and sinus rhythm. (Echocardiography 2011;28:62-68).
Authors:
Yelda Basaran; Kursat Tigen; Tansu Karaahmet; Iclal Isiklar; Cihan Cevik; Emre Gurel; Cihan Dundar; Selcuk Pala; Kamran Mahmutyazicioglu; Ozcan Basaran
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  28     ISSN:  1540-8175     ISO Abbreviation:  Echocardiography     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Copyright Information:
© 2010, Wiley Periodicals, Inc.
Affiliation:
Cardiology Department, Kartal Kosuyolu Heart Education and Research Hospital, Istanbul, Turkey Department of Radiology, Baskent University School of Medicine, Istanbul, Turkey Texas Heart Institute St. Luke's Episcopal Hospital, Cardiology Division, Houston, Texas Sema Hospital Department of Radiology, Istanbul, Turkey.
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