Document Detail

Fragmented QRS Complex in Adult Patients with Ebstein's Anomaly and Its Association with Arrhythmic Risk and the Severity of the Anomaly.
MedLine Citation:
PMID:  24235269     Owner:  NLM     Status:  Publisher    
BACKGROUND: -Fragmented QRS complex (fQRS) on 12-lead ECG, a marker of myocardial scar, is a predictor of arrhythmic events in patients with ischemic and non-ischemic cardiomyopathy. We investigated whether the presence of fQRS is associated with the severity of the anomaly and with increased arrhythmic events in adult patients with Ebstein's anomaly (EA).
METHODS AND RESULTS: -In 51 consecutive adult EA patients (median age, 37 years; 18 males), the severity index of EA calculated from echocardiographic data and clinical arrhythmic events were analyzed. The extent of fQRS in each patient was measured by counting the number of ECG leads showing fQRS. There were 35 (68.6%) patients with fQRS (fQRS group) and 16 (31.4%) patients without fQRS (non-fQRS group). fQRS was observed more frequently in the inferior (n=26) and precordial (n=25) leads versus the lateral leads (n=5). The patients in the fQRS group had a worse functional class, greater cardiothoracic ratios, more severe tricuspid regurgitation, larger atrialized right ventricular (aRV) areas, higher EA severity scores, and more frequent arrhythmic events compared to those in the non-fQRS group. The aRV area showed a positive correlation with the fQRS extent (r=0.51, P<0.001). In multivariable Cox regression models, the presence of fQRS was independently associated with arrhythmic events (P=0.036).
CONCLUSIONS: -Fragmented QRS on 12-lead ECG was associated with larger aRV area and an increased risk of arrhythmic events in adult patients with EA.
Seung-Jung Park; Seungmin Chung; Young Geun On; June Soo Kim; Ji-Hyuk Yang; Tae-Gook Jun; Shin Yi Jang; Ok Jung Lee; Jinyoung Song; I-Seok Kang; June Huh
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-14
Journal Detail:
Title:  Circulation. Arrhythmia and electrophysiology     Volume:  -     ISSN:  1941-3084     ISO Abbreviation:  Circ Arrhythm Electrophysiol     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101474365     Medline TA:  Circ Arrhythm Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
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