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Fragmentation investigation of seven arylnaphthalide lignans using liquid chromatography/tandem quadrupole time-of-flight mass spectrometry.
MedLine Citation:
PMID:  22396032     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
RATIONALE: The combination of fragmentation patterns in positive and negative ion modes could be helpful in understanding the structural features of these arylnaphthalide lignans.
METHODS: Fragmentation patterns of seven arylnaphthalide lignans were investigated using liquid chromatography/tandem time-of-flight mass spectrometry, and their fragmentation pathways were comprehensively characterized.
RESULTS: In the positive ion mode, the cleavage of the C-1'-C-7' bond was the most characteristic fragmentation pattern of the lignans with both 2'-hydroxy and 4',5'-methylenedioxy groups on the B ring. Arylnaphthalide lignans containing a methylenedioxy group on the B ring could lose C(2) H(2) O(2) easily. The characteristic mass losses of 58 Da (C(2) H(2) O(2) ) could indicate the presence of a methylenedioxy group on the B ring. In the negative ion mode, the type of substituents at C-7 could affect the cleavage pattern of the lactone ring.
CONCLUSIONS: In search for new compounds, and also in quality control, there is a need to have reliable methodology for the analysis of arylnaphthalide lignans. These results should be useful in the analysis of natural products with similar substructures from Chinese herbs in the future. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
Wei Li; Meihua Yang; Yuguo Zheng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  26     ISSN:  1097-0231     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  950-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100193, P.R. China.
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