Document Detail

Fragment Bb: evidence for activation of the alternative pathway of the complement system in pregnant women with acute pyelonephritis.
MedLine Citation:
PMID:  20218820     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Pyelonephritis during pregnancy is associated with a more severe course than in the non-pregnant state. This has been attributed to an increased susceptibility of pregnant women to microbial products. The complement system is part of innate immunity and its alternative pathway is activated mainly by microorganisms. The purpose of this study was to determine if activation of the alternative pathway of the complement system (determined by maternal fragment Bb concentrations) occurs in pregnant women with acute pyelonephritis.
METHODS: This cross-sectional study included the following groups: (1) normal pregnant women (n=62) and (2) pregnant women with pyelonephritis (n=38). Maternal plasma fragment Bb concentrations were determined by ELISA. Non-parametric statistics were used for analyses.
RESULTS: (1) Pregnant women with pyelonephritis had a higher median plasma concentration of fragment Bb than those with a normal pregnancy (1.3 μg/ml, IQR: 1.1-1.9 vs. 0.8 μg/ml, IQR: 0.7-0.9; p<0.001); (2) No significant differences were observed in the median maternal plasma concentration of fragment Bb between pregnant women with pyelonephritis who had a positive blood culture and those with a negative blood culture (1.4 μg/ml, IQR: 1.1-3.5 vs. 1.3 μg/ml, IQR: 1.1-1.9; p=0.2).
CONCLUSIONS: Pregnant women with acute pyelonephritis have evidence of activation of the alternative pathway of the complement system, regardless of the presence or absence of a positive blood culture.
Eleazar Soto; Roberto Romero; Edi Vaisbuch; Offer Erez; Shali Mazaki-Tovi; Juan Pedro Kusanovic; Zhong Dong; Tinnakorn Chaiworapongsa; Lami Yeo; Pooja Mittal; Sonia S Hassan
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2011-01-06     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1085-90     Citation Subset:  IM    
Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland, USA.
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MeSH Terms
Complement Factor B / analysis,  immunology*
Complement Pathway, Alternative / immunology*
Cross-Sectional Studies
Pregnancy Complications, Infectious / blood,  immunology*
Pyelonephritis / blood,  complications,  immunology*
Young Adult
Grant Support
Reg. No./Substance:
EC Factor B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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