| Fragile x syndrome and autism: from disease model to therapeutic targets. | |
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MedLine Citation:
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PMID: 21547712 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Autism is an umbrella diagnosis with several different etiologies. Fragile X syndrome (FXS), one of the first identified and leading causes of autism, has been modeled in mice using molecular genetic manipulation. These Fmr1 knockout mice have recently been used to identify a new putative therapeutic target, the metabotropic glutamate receptor 5 (mGluR5), for the treatment of FXS. Moreover, mGluR5 signaling cascades interact with a number of synaptic proteins, many of which have been implicated in autism, raising the possibility that therapeutic targets identified for FXS may have efficacy in treating multiple other causes of autism. |
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Authors:
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Gül Dölen; Mark F Bear |
Publication Detail:
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Type: Journal Article Date: 2009-05-12 |
Journal Detail:
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Title: Journal of neurodevelopmental disorders Volume: 1 ISSN: 1866-1955 ISO Abbreviation: J Neurodev Disord Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2011-05-06 Completed Date: 2011-07-14 Revised Date: 2011-12-20 |
Medline Journal Info:
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Nlm Unique ID: 101483832 Medline TA: J Neurodev Disord Country: United States |
Other Details:
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Languages: eng Pagination: 133-40 Citation Subset: - |
Affiliation:
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Department of Brain and Cognitive Sciences, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA, guldolen@gmail.com. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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