| Fragile X tremor/ataxia syndrome: blame the messenger! | |
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MedLine Citation:
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PMID: 17698005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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rCGG repeats in premutant alleles of the fragile X gene (FMR1) cause neurodegeneration in Drosophila and are thought to cause fragile X-associated tremor/ataxia syndrome in humans. Two reports in this issue of Neuron (Jin et al. and Sofola et al.) present data indicating a disease mechanism involving disruption of RNA-binding protein function. |
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Authors:
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Maurice S Swanson; Harry T Orr |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: Neuron Volume: 55 ISSN: 0896-6273 ISO Abbreviation: Neuron Publication Date: 2007 Aug |
Date Detail:
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Created Date: 2007-08-16 Completed Date: 2007-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809320 Medline TA: Neuron Country: United States |
Other Details:
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Languages: eng Pagination: 535-7 Citation Subset: IM |
Affiliation:
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Department of Molecular Genetics and Microbiology, University of Florida, College of Medicine, Cancer Genetics Research Complex, 1376 Mowry Road, Gainesville, FL 32610-3610, USA. orrxx002@umn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila Proteins / genetics Fragile X Mental Retardation Protein / genetics Fragile X Syndrome / complications, genetics, metabolism* Humans Models, Biological Neurodegenerative Diseases / etiology, genetics, metabolism RNA-Binding Proteins / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/FMR1 protein, Drosophila; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
| Comments/Corrections | |
Comment On:
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Neuron. 2007 Aug 16;55(4):565-71
[PMID:
17698010
]
Neuron. 2007 Aug 16;55(4):556-64 [PMID: 17698009 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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