| Fragile X syndrome and acute lymphoblastic leukemia. | |
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MedLine Citation:
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PMID: 3179954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X [Fra(X)] syndrome is an example of a heritable fragility syndrome associated with mental retardation. It is characterized by a fragile site on the X chromosome at Xq27-28. There have recently been three reports of malignant solid tumors associated with Fra(X) syndrome. We describe the first case of a hematologic malignancy [T-cell acute lymphocytic leukemia (ALL)] in a patient with Fra(X) syndrome. The possibility of a predisposition to malignancy in Fra(X) is discussed. |
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Authors:
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M Cunningham; J D Dickerman |
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11007554 - Dendritic spine structural anomalies in fragile-x mental retardation syndrome. 3779244 - Prevalence of the fragile x syndrome in an institution for the mentally handicapped. 8158744 - Horner's syndrome following a thyroidectomy. 17194594 - Tremor/ataxia syndrome and fragile x premutation: diagnostic caveats. 8170264 - The antiphospholipid and thrombosis syndromes. 3668764 - Adie's syndrome as a cause of amblyopia. |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer Volume: 62 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1988-12-12 Completed Date: 1988-12-12 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2383-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of Vermont, College of Medicine, Burlington, VT 05405. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Child, Preschool Fragile X Syndrome / complications* Humans Karyotyping Male Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications* Sex Chromosome Aberrations / complications* |
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