| Fragile X syndrome. Molecular and clinical insights and treatment issues. | |
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MedLine Citation:
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PMID: 9109330 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fragile X syndrome is the most common inherited cause of mental retardation that is known. The prevalence of mental retardation from this syndrome ranges from 1 in 1,250 to 1 in 4,000 in the general population, although the prevalence of female carriers has been reported to be as high as 1 in 259. The discovery of the FMR1 gene mutation in 1991 has simplified diagnosis, enhanced our understanding of the spectrum of involvement in the fragile X syndrome, and stimulated research regarding the normal function of the FMR1 protein in brain development. Advances have also occurred in the treatment of the fragile X syndrome, and psychopharmacologic and educational interventions are reviewed here. |
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Authors:
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R J Hagerman |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Western journal of medicine Volume: 166 ISSN: 0093-0415 ISO Abbreviation: West. J. Med. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-05-09 Completed Date: 1997-05-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0410504 Medline TA: West J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 129-37 Citation Subset: AIM; IM |
Affiliation:
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Child Development Unit, Children's Hospital, Denver, CO 80218, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Diagnosis, Differential Female Follow-Up Studies Fragile X Syndrome / complications, diagnosis*, drug therapy, genetics Humans Incidence Male Mental Disorders / drug therapy, epidemiology, etiology* Psychotropic Drugs / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Psychotropic Drugs |
| Comments/Corrections | |
Comment In:
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West J Med. 1997 Feb;166(2):150-1
[PMID:
9109337
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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