| Fragile X protein expression is linked to visual functions in healthy male volunteers. | |
| | |
MedLine Citation:
|
PMID: 21749915 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Fragile X syndrome (FXS) is characterized by the impairment of the magnocellular/dorsal visual system. In this study, we explored how fragile X protein (FMRP) expression may affect visual functions in healthy participants. The percentage of FMRP-positive lymphocytes was measured using a rapid antibody test in blood smears of 100 male volunteers. CGG triplet expansion was also determined. Results revealed that participants with fewer FMRP-positive lymphocytes exhibited lower performances on tests biasing information processing toward the magnocellular pathway and dorsal visual stream (contrast sensitivity at low spatial/high temporal frequency and motion coherence). It was not observed in the case of tests biasing information processing toward the parvocellular pathway and ventral stream (contrast sensitivity at high spatial/low temporal frequency and form coherence). These results suggest that healthy persons with lower peripheral FMRP expression display a visual phenotype similar to that described in patients with FXS. |
| | |
Authors:
|
S Kéri; G Benedek |
Related Documents
:
|
10580725 - Electroretinogram of the parietal eye of lizards: photoreceptor, glial, and lens cell c... 2361195 - Maturation of the photopic b-wave and oscillatory potentials of the electroretinogram i... 15924945 - Modulation of the human photopic erg luminance-response function with the use of chroma... 6813195 - Clinical erg findings in ethambutol intoxication. 3411035 - Frequency specific susceptibility to acoustic trauma in the budgerigar (melopsittacus u... 18682745 - Ubiquitous crossmodal stochastic resonance in humans: auditory noise facilitates tactil... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-1 |
Journal Detail:
|
Title: Neuroscience Volume: - ISSN: 1873-7544 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
|
Department of Physiology, University of Szeged, Szeged, Hungary; National Psychiatry Center, Budapest, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Fitts task reveals impairments in planning and online control of movement in Friedreich ataxia: ...
Next Document: Cytotoxic sesquiterpenoids from the fruits of Lindera communis.