| Fragile X mental retardation protein in plasticity and disease. | |
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MedLine Citation:
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PMID: 12424729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fragile X syndrome is the most common cause of mental retardation known to be inherited. The syndrome results from the suppressed expression of a single protein, the fragile X mental retardation protein (FMRP). Understanding the function and regulation of FMRP can, therefore, offer insights into both the pathophysiology of fragile X syndrome and the molecular mechanisms of learning and memory. We provide an overview of current concepts of how FMRP functions in the nervous system, with special emphasis on recent evidence that FMRP has a role in metabotropic glutamate receptor-activated protein translation and synaptic plasticity. |
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Authors:
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Peter K Todd; James S Malter |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of neuroscience research Volume: 70 ISSN: 0360-4012 ISO Abbreviation: J. Neurosci. Res. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-08 Completed Date: 2003-01-23 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600111 Medline TA: J Neurosci Res Country: United States |
Other Details:
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Languages: eng Pagination: 623-30 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Wiley-Liss, Inc. |
Affiliation:
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Department of Pathology, Medical Scientist and Neuroscience Training Program, University of Wisconsin, 600 Highland Drive, Madison, WI 53792, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fragile X Mental Retardation Protein Fragile X Syndrome / physiopathology* Humans Nerve Tissue Proteins / physiology* Neuronal Plasticity / physiology* RNA-Binding Proteins* |
| Chemical | |
Reg. No./Substance:
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0/FMR1 protein, human; 0/Nerve Tissue Proteins; 0/RNA-Binding Proteins; 139135-51-6/Fragile X Mental Retardation Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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