Document Detail


Fractured carbon fiber-based biosensor for glucose.
MedLine Citation:
PMID:  8017636     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A microsensor for glucose was constructed using DuPont E120 fibers, which exhibit extensive fracturing upon severe anodic pretreatment. The fracturing is accompanied by an increase in the electrochemical surface area of several orders of magnitude, which is exploited here in the design of a microsensor. Following fracture, the fibers were platinized to enhance their ability to detect enzymatically produced hydrogen peroxide, and glucose oxidase was immobilized at the surface of the fiber in polypyrrole. When operated amperometrically in flow injection analysis, the treated electrodes showed a linear response to injected glucose concentration up to 10 mM, with an observed Km' near 20 mM. The sensors were found to be stable for up to 2 months when stored dry at 4 degrees C.
Authors:
J W Furbee; T Kuwana; R S Kelly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Analytical chemistry     Volume:  66     ISSN:  0003-2700     ISO Abbreviation:  Anal. Chem.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-07-28     Completed Date:  1994-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1575-7     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Lake Forest College, Illinois 60045.
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MeSH Terms
Descriptor/Qualifier:
Biosensing Techniques*
Carbon*
Enzymes, Immobilized / metabolism
Glucose / analysis*
Glucose Oxidase / metabolism
Chemical
Reg. No./Substance:
0/Enzymes, Immobilized; 50-99-7/Glucose; 7440-44-0/Carbon; EC 1.1.3.4/Glucose Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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