Document Detail


Fractone-associated N-sulfated heparan sulfate shows reduced quantity in BTBR T+tf/J mice: a strong model of autism.
MedLine Citation:
PMID:  22101175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BTBR T+tf/J (BTBR) mice show abnormal social, communicatory, and repetitive/stereotyped behaviors paralleling many of the symptoms of autism spectrum disorders. BTBR also show agenesis of the corpus callosum (CC) suggesting major perturbations of growth or guidance factors in the dorsal forebrain [1]. Heparan sulfate (HS) is a polysaccaride found in the brain and other animal tissues. It binds to a wide variety of ligands and through these ligands modulates a number of biological processes, including cell proliferation and differentiation, migration and guidance. It is aggregated on fractal-like structures (fractones) in the subventricular zone (SVZ), that may be visualized by laminin immunoreactivity (LAM-ir), as well as by HS immunoreactivity (HS-ir). We report that the lateral ventricles of BTBR mice were drastically reduced in area compared to C57BL/6J (B6) mice while the BTBR SVZ was significantly shorter than that of B6. In addition to much smaller fractones for BTBR, both HS and LAM-ir associated with fractones were significantly reduced in BTBR, and their anterior-posterior distributions were also altered. Finally, the ratio of HS to LAM in individual fractones was significantly higher in BTBR than in B6 mice. These data, in agreement with other findings linking HS to callosal development, suggest that variations in the quantity and distribution of HS in the SVZ of the lateral ventricles may be important modulators of the brain structural abnormalities of BTBR mice, and, potentially, contribute to the behavioral pathologies of these animals.
Authors:
Ksenia Z Meyza; D Caroline Blanchard; Brandon L Pearson; Roger L H Pobbe; Robert J Blanchard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-11-12
Journal Detail:
Title:  Behavioural brain research     Volume:  228     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-05-23     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  247-53     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Autistic Disorder / genetics,  metabolism*,  pathology*,  physiopathology
Brain / pathology
Corpus Callosum / metabolism,  pathology
Disease Models, Animal
Heparitin Sulfate / metabolism*
Lamins / metabolism
Lateral Ventricles / metabolism*,  pathology*
Male
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Phenotype
Grant Support
ID/Acronym/Agency:
MH081845/MH/NIMH NIH HHS; R01 MH081845/MH/NIMH NIH HHS; R01 MH081845-03/MH/NIMH NIH HHS; R01 MH081845-04/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Lamins; 9050-30-0/Heparitin Sulfate
Comments/Corrections

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