Document Detail

Fractionated stereotactic radiotherapy treatment of cavernous sinus meningiomas: a study of 100 cases.
MedLine Citation:
PMID:  19117697     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We discuss our experiences with fractionated stereotactic radiotherapy (FSR) in the treatment of cavernous sinus meningiomas. METHODS AND MATERIALS: From 1995 to 2006, we monitored 100 patients diagnosed with cavernous sinus meningiomas; 84 female and 16 male patients were included. The mean patient age was 56 years. The most common symptoms were a reduction in visual acuity (57%), diplopia (50%), exophthalmy (30%), and trigeminal neuralgia (34%). Surgery was initially performed on 26 patients. All patients were treated with FSR. A total of 45 Gy was administered to the lesion, with 5 fractions of 1.8 Gy completed each week. Patient treatment was performed using a Varian Clinac linear accelerator used for cranial treatments and a micro-multileaf collimator. RESULTS: No side effects were reported. Mean follow-up period was 33 months, with 20% of patients undergoing follow-up evaluation of more than 4 years later. The tumor control rate at 3 years was 94%. Three patients required microsurgical intervention because FSR proved ineffective. In terms of functional symptoms, an 81% improvement was observed in patients suffering from exophthalmy, with 46% of these patients being restored to full health. A 52% improvement was observed in diplopia, together with a 67% improvement in visual acuity and a 50% improvement in type V neuropathy. CONCLUSIONS: FSR facilitates tumor control, either as an initial treatment option or in combination with microsurgery. In addition to being a safe procedure with few side effects, FSR offers the significant benefit of superior functional outcomes.
Claude Fabien Litré; Philippe Colin; Remy Noudel; Philippe Peruzzi; Arnaud Bazin; Bernard Sherpereel; Marie Helene Bernard; Pascal Rousseaux
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Publication Detail:
Type:  Journal Article     Date:  2008-12-30
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  74     ISSN:  1879-355X     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-23     Completed Date:  2009-07-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1012-7     Citation Subset:  IM    
Department of Neurosurgery, Maison Blanche Hospital, Reims, France.
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MeSH Terms
Cavernous Sinus*
Follow-Up Studies
Magnetic Resonance Imaging
Meningeal Neoplasms / complications,  pathology,  surgery*
Meningioma / complications,  pathology,  surgery*
Middle Aged
Radiosurgery / methods*
Treatment Outcome
Tumor Burden

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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