Document Detail

Fractionated stereotactic radiosurgery for treatment of acoustic neuromas.
MedLine Citation:
PMID:  10853097     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Microsurgery and single-fraction radiosurgery for acoustic neuromas are associated with high rates of control, but can result in facial palsy and trigeminal neuropathy. To reduce the morbidity of treatment for acoustic neuromas while maintaining efficacy, we explored fractionated stereotactic radiosurgery (FSR). METHODS: We reviewed data for 31 acoustic neuromas in 30 patients treated with 25 Gy (linear accelerator) given in 5 consecutive daily fractions. The minimum follow-up was 6 months (6-44 months). The mean tumor volume was 1.1 cm(3) (0.1-8.74 cm(3)). RESULTS: All tumors remain controlled (9 smaller, 22 unchanged). No patient has experienced post-radiosurgery facial motor dysfunction. Two patients developed new trigeminal neuropathy; 2 patients with preexisting trigeminal nerve symptoms had improvement after FSR. Balance improved in 3 patients, was unchanged in 20 and worsened in 7 patients. Of the 12 patients with useful hearing (PTA < or = 50 dB) prior to treatment, 9 patients retained useful hearing following FSR. Subjectively, of 25 patients with any hearing prior to treatment, 2 had improvement, 10 remained unchanged and 13 had worsening. CONCLUSIONS: Short course FSR for acoustic neuromas results in acceptable toxicity and may provide high control of tumors. Longer follow-up is needed to assess outcomes.
D Y Song; J A Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stereotactic and functional neurosurgery     Volume:  73     ISSN:  1011-6125     ISO Abbreviation:  Stereotact Funct Neurosurg     Publication Date:  1999  
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8902881     Medline TA:  Stereotact Funct Neurosurg     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Johns Hopkins Oncology Center, Division of Radiation Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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MeSH Terms
Middle Aged
Neuroma, Acoustic / physiopathology,  surgery*
Postoperative Complications
Postoperative Period
Postural Balance
Radiosurgery / methods*
Stereotaxic Techniques*
Trigeminal Nerve Diseases / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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