| Fractionated wide-field radiation therapy followed by fractionated local-field irradiation for treating widespread painful bone metastasis. | |
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MedLine Citation:
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PMID: 20399031 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Wide-field radiation therapy (WFRT) is an effective treatment for widespread bone metastasis. We evaluated local-field irradiation (LFI) after fractionated WFRT (f-WFRT) for treating the patients with multiple painful bone lesions. METHODS AND MATERIALS: From 1998 to 2007, 32 patients with multiple bone metastases were treated with fractionated LFI (f-LFI) after f-WFRT. All patients initially received 15 Gy in 5 fractions to a wide field, followed by LFI (9-15 Gy in 3 Gy fractions). Response was assessed by evaluating the degree of pain relief using a visual analog scale before radiotherapy, after f-WFRT, and after f-LFI. RESULTS: Fractionated LFI following f-WFRT yielded an overall relief rate of 93.8% and a complete relief rate of 43.8%. The rate of the appearance of new disease was 6.3% for the patients with complete relief, 20.5% for the patients with a partial relief, and 50% for the patients with no relief. CONCLUSION: Fractionated LFI after f-WFRT is a well-tolerated and effective treatment for multiple metastatic bone disease. |
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Authors:
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Yongkan Ki; Wontaek Kim; Jiho Nam; Donghyun Kim; Hosang Jeon; Dahl Park; Dongwon Kim |
Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-04-14 |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 79 ISSN: 1879-355X ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 220-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiation Oncology, Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bone Neoplasms / mortality, radiotherapy*, secondary* Female Humans Male Middle Aged Pain / radiotherapy* Pain Measurement Radiotherapy / adverse effects, methods Survival Analysis Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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