Document Detail

Fractional urinary fluoride excretion of young female adults during the diurnal and nocturnal periods.
MedLine Citation:
PMID:  18523387     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study aimed to confirm a previously obtained value for the fractional urinary fluoride excretion (FUFE) over a 24-hour period in adults and to assess whether there are significant differences between FUFE measured during the diurnal (7 a.m. and 6 p.m.) and the subsequent nocturnal (6 p.m. until 7 a.m. of the following day) periods. METHODS: Urine was collected over 24 h from 60 healthy female volunteers residing in Santiago, Chile. The individuals' fluoride intakes over the diurnal and nocturnal periods were calculated from their corresponding F ingestion, measured by dietary analysis. Separate urine collections during both periods were obtained from each volunteer. The fluoride concentrations were measured with a fluoride-ion-selective electrode either directly (urine, water and beverages) or after sample treatment with the microdiffusion technique (food). RESULTS: The average 24-hour FUFE value was 0.69, with a 95% CI of 0.65-0.72, while the average FUFE for the diurnal period was 0.46 (95% CI: 0.42-0.50), and the corresponding result for the nocturnal period showed a significantly higher (paired t test, p < 0.0001) amount of 1.09 (95% CI: 0.97-1.22). CONCLUSIONS: A recently published result for the daily FUFE value (0.71) in adults was confirmed. The diurnal average FUFE value is significantly lower than the average nocturnal one. Accepting that approximately 10% of the fluoride intake is not absorbed, the daily fluoride retention can be preliminarily estimated as 20% of the ingested fluoride.
A Villa; M Anabalón; L Cabezas; A Rugg-Gunn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-04
Journal Detail:
Title:  Caries research     Volume:  42     ISSN:  1421-976X     ISO Abbreviation:  Caries Res.     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-15     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0103374     Medline TA:  Caries Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  275-81     Citation Subset:  D; IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Institute of Nutrition and Food Technology, INTA, University of Chile, Santiago, Chile.
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MeSH Terms
Cariostatic Agents / administration & dosage,  pharmacokinetics*
Circadian Rhythm / physiology*
Fluorides / administration & dosage,  pharmacokinetics,  urine*
Metabolic Clearance Rate
Reference Values
Statistics, Nonparametric
Reg. No./Substance:
0/Cariostatic Agents; 0/Fluorides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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