Document Detail

Fractional sodium excretion, urinary osmolality and specific gravity in preterm infants fed with fortified donor human milk.
MedLine Citation:
PMID:  16871349     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This research was performed with the objective of investigating the renal effects on premature newborn infants of fortifying banked donor human milk. METHODS: Clinical intervention trial, of the before-and-after type, involving 28 premature newborn infants split into two groups by postconceptional age at the start of the study: GI < 34 weeks (n = 14) and GII >or= 34 weeks (n = 14), and assessed at three sample points: S1, on unfortified donor human milk, S2, after 3 days, and S3, after 10-13 days on fortified donor human milk. Nutrient intake, weight gain, fractional sodium excretion, urinary osmolality and specific density were compared with two-way ANOVA for repeated measures. RESULTS: Fluids, energy and sodium intakes were similar for both groups, and weight gain was satisfactory. Among the preterms with < 34 weeks postconceptional age, serum sodium was lower at the end of the study and the fractional sodium excretion was elevated at the start and at the end of the study (S1 = 2.11+/-1.05; S2 = 1.25+/-0.64; S3 = 1.62+/-0.88), with a significant difference in relation to GII (S1 = 1.34+/-0.94; S2 = 0.90+/-0.54; S3 = 0.91+/-0.82). Osmolality and urinary specific density were normal, with no differences between groups or collection dates. CONCLUSIONS: No adverse effects on the renal function of these preterms were detected as a result of being fed fortified donor human milk.
Atsuko Tanaka; Ligia M S S Rugolo; Antero F M Miranda; Cleide E P Trindade
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2006-07-21
Journal Detail:
Title:  Jornal de pediatria     Volume:  82     ISSN:  0021-7557     ISO Abbreviation:  J Pediatr (Rio J)     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-09     Completed Date:  2007-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
Departamento de Pediatria, Faculdade de Medicina de Marília, Marília, SP, Brasil.
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MeSH Terms
Analysis of Variance
Calcium, Dietary / administration & dosage
Food, Fortified*
Gestational Age
Infant Formula*
Infant, Newborn
Infant, Premature / metabolism*
Infant, Very Low Birth Weight / metabolism*
Milk, Human*
Osmolar Concentration
Phosphorus, Dietary / administration & dosage
Sodium / blood,  urine*
Sodium, Dietary / administration & dosage*
Specific Gravity
Urine / chemistry
Weight Gain
Reg. No./Substance:
0/Calcium, Dietary; 0/Phosphorus, Dietary; 0/Sodium, Dietary; 7440-23-5/Sodium
Comment In:
J Pediatr (Rio J). 2006 Sep-Oct;82(5):317-8   [PMID:  17028761 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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