Document Detail


Fractional exhaled nitric oxide exchange parameters among 9-year-old inner-city children.
MedLine Citation:
PMID:  20848585     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES AND HYPOTHESIS: To determine the feasibility of using a multiple flow offline fractional exhaled nitric oxide (FeNO) collection method in an inner-city cohort and determine this population's alveolar and conducting airway contributions of NO. We hypothesized that the flow independent NO parameters would be associated differentially with wheeze and seroatopy.
METHODS: As part of a birth cohort study, 9-year-old children (n=102) of African-American and Dominican mothers living in low-income NYC neighborhoods had FeNO samples collected offline at constant flow rates of 50, 83, and 100 ml/sec. Seroatopy was defined as having measurable (≥ 0.35 IU/ml) specific IgE to any of the five inhalant indoor allergens tested. Current wheeze (last 12 months) was assessed by ISAAC questionnaire. Bronchial NO flux (J(NO) ) and alveolar NO concentration (C(alv)) were estimated by the Pietropaoli and Hogman methods.
RESULTS: Valid exhalation flow rates were achieved in 96% of the children. Children with seroatopy (53%) had significantly higher median J(NO) (522 pl/sec vs. 161 pl/sec, P<0.001) when compared to non-seroatopic children; however, median C(alv) was not significantly different between these two groups (5.5 vs. 5.8, P=0.644). Children with wheeze in the past year (21.6%) had significantly higher median C(alv) (8.4 ppb vs. 4.9 ppb, P<0.001), but not J(NO) (295 pl/sec vs. 165 pl/sec, P=0.241) when compared with children without wheeze. These associations remained stable after adjustment for known confounders/covariates.
CONCLUSIONS: The multiple flow method was easily implemented in this pediatric inner-city cohort. In this study population, alveolar concentration of NO may be a better indicator of current wheeze than single flow FeNO.
Authors:
Maria José Rosa; Adnan Divjan; Lori Hoepner; Beverley J Sheares; Diurka Diaz; Kevin Gauvey-Kern; Frederica P Perera; Rachel L Miller; Matthew S Perzanowski
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-09-16
Journal Detail:
Title:  Pediatric pulmonology     Volume:  46     ISSN:  1099-0496     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-29     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Allergens / immunology
Asthma / epidemiology
Breath Tests / methods
Child
Cohort Studies
Exhalation / physiology
Female
Humans
Immunoglobulin E / blood
Male
New York City
Nitric Oxide / physiology*
Poverty
Pulmonary Gas Exchange / physiology*
Respiratory Sounds / diagnosis*,  physiopathology
Urban Population
Grant Support
ID/Acronym/Agency:
P01 ES009600/ES/NIEHS NIH HHS; P01 ES009600-12/ES/NIEHS NIH HHS; P01 ES09600/ES/NIEHS NIH HHS; P30 ES009089/ES/NIEHS NIH HHS; P30 ES009089/ES/NIEHS NIH HHS; P30 ES009089-11/ES/NIEHS NIH HHS; P50 ES015905/ES/NIEHS NIH HHS; P50 ES015905/ES/NIEHS NIH HHS; P50 ES015905-05/ES/NIEHS NIH HHS; R01 ES008977/ES/NIEHS NIH HHS; R01 ES008977-12S1/ES/NIEHS NIH HHS; R01 ES08977/ES/NIEHS NIH HHS; RR00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Allergens; 31C4KY9ESH/Nitric Oxide; 37341-29-0/Immunoglobulin E
Comments/Corrections

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