| Fraction of exhaled nitric oxide in patients with acute eosinophilic pneumonia. | |
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MedLine Citation:
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PMID: 22016484 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Acute eosinophilic pneumonia (AEP) is an idiopathic disease characterized by pulmonary eosinophilia. Because the fraction of exhaled nitric oxide (Feno) is a surrogate of eosinophilic inflammation, we evaluated the levels, changed treatments, and the diagnostic role of Feno in patients with AEP. METHODS: Between June 2010 and March 2011, we prospectively enrolled patients at the Armed Forces Capital Hospital who had pulmonary infiltrates and a febrile illness and who were clinically suspected to have AEP. We measured Feno twice at the initial visit (pretreatment) and 2 weeks after the initial measurement (posttreatment). RESULTS: A total of 60 subjects were enrolled, and 31 were given a diagnosis of AEP. The pretreatment Feno levels of the patients with AEP were significantly higher than those of the patients without AEP (median, 48 parts per billion [ppb] [range, 10-138] vs 14 ppb [range, 5-41]; P < .001). The cut-off value (23.5 ppb) showed that the maximal area under the receiver operating characteristic curve predicted AEP with a sensitivity of 0.87 and a specificity of 0.83. The posttreatment Feno levels decreased significantly in the patients with AEP, and the levels were similar to the patients without AEP (median, 19 ppb [range, 7-44] vs 14 ppb [range, 1-58]; P = .21) CONCLUSIONS: The Feno level was significantly higher in patients with AEP than in those without AEP. Feno measurement can be used as a diagnostic tool to differentiate patients with AEP from those without AEP. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01152424; URL: www.clinicaltrials.gov. |
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Authors:
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Ji Eun Lee; Chin Kook Rhee; Ji Hwan Lim; Sang Min Lee; Young Soo Shim; Choon-Taek Lee; Sei Won Lee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-10-20 |
Journal Detail:
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Title: Chest Volume: 141 ISSN: 1931-3543 ISO Abbreviation: Chest Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-03 Completed Date: 2012-06-25 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 1267-72 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, The Armed Forces Capital Hospital, Seoul, Republic of Korea. |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT01152424 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Administration, Oral Adolescent Anti-Inflammatory Agents / administration & dosage Biological Markers / analysis Breath Tests / methods* Bronchoalveolar Lavage Fluid Bronchoscopy Diagnosis, Differential Female Humans Infusions, Intravenous Male Methylprednisolone / administration & dosage Nitric Oxide / analysis* Predictive Value of Tests Prednisolone / administration & dosage Prospective Studies Pulmonary Eosinophilia / diagnosis*, drug therapy Reference Values Republic of Korea Tomography, X-Ray Computed Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Biological Markers; 10102-43-9/Nitric Oxide; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone |
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