Document Detail


Fraction of exhaled nitric oxide in patients with acute eosinophilic pneumonia.
MedLine Citation:
PMID:  22016484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acute eosinophilic pneumonia (AEP) is an idiopathic disease characterized by pulmonary eosinophilia. Because the fraction of exhaled nitric oxide (Feno) is a surrogate of eosinophilic inflammation, we evaluated the levels, changed treatments, and the diagnostic role of Feno in patients with AEP.
METHODS: Between June 2010 and March 2011, we prospectively enrolled patients at the Armed Forces Capital Hospital who had pulmonary infiltrates and a febrile illness and who were clinically suspected to have AEP. We measured Feno twice at the initial visit (pretreatment) and 2 weeks after the initial measurement (posttreatment).
RESULTS: A total of 60 subjects were enrolled, and 31 were given a diagnosis of AEP. The pretreatment Feno levels of the patients with AEP were significantly higher than those of the patients without AEP (median, 48 parts per billion [ppb] [range, 10-138] vs 14 ppb [range, 5-41]; P < .001). The cut-off value (23.5 ppb) showed that the maximal area under the receiver operating characteristic curve predicted AEP with a sensitivity of 0.87 and a specificity of 0.83. The posttreatment Feno levels decreased significantly in the patients with AEP, and the levels were similar to the patients without AEP (median, 19 ppb [range, 7-44] vs 14 ppb [range, 1-58]; P = .21)
CONCLUSIONS: The Feno level was significantly higher in patients with AEP than in those without AEP. Feno measurement can be used as a diagnostic tool to differentiate patients with AEP from those without AEP.
TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT01152424; URL: www.clinicaltrials.gov.
Authors:
Ji Eun Lee; Chin Kook Rhee; Ji Hwan Lim; Sang Min Lee; Young Soo Shim; Choon-Taek Lee; Sei Won Lee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-20
Journal Detail:
Title:  Chest     Volume:  141     ISSN:  1931-3543     ISO Abbreviation:  Chest     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-03     Completed Date:  2012-06-25     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1267-72     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, The Armed Forces Capital Hospital, Seoul, Republic of Korea.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01152424
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Administration, Oral
Adolescent
Anti-Inflammatory Agents / administration & dosage
Biological Markers / analysis
Breath Tests / methods*
Bronchoalveolar Lavage Fluid
Bronchoscopy
Diagnosis, Differential
Female
Humans
Infusions, Intravenous
Male
Methylprednisolone / administration & dosage
Nitric Oxide / analysis*
Predictive Value of Tests
Prednisolone / administration & dosage
Prospective Studies
Pulmonary Eosinophilia / diagnosis*,  drug therapy
Reference Values
Republic of Korea
Tomography, X-Ray Computed
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biological Markers; 10102-43-9/Nitric Oxide; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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