| Fraction of Exhaled Nitric Oxide in Patients with Acute Eosinophilic Pneumonia. | |
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MedLine Citation:
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PMID: 22016484 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT BACKGROUND:Acute eosinophilic pneumonia (AEP) is an idiopathic disease characterized by pulmonary eosinophilia. Since the fraction of exhaled nitric oxide (FeNO) is a surrogate of eosinophilic inflammation, we evaluated the levels, changed treatments and the diagnostic role of FeNO in patients with AEP. METHODS:We prospectively enrolled patients at the Armed Forces Capital Hospital who had diffuse pulmonary infiltrates and a febrile illness and who were clinically suspected to have AEP between June 2010 and March 2011. We measured FeNO twice at the initial visit (pre-treatment) and two weeks after the initial measurement (post-treatment). RESULTS:A total of 60 subjects were enrolled and 31 were diagnosed with AEP. The pre-treatment FeNO levels of the patients with AEP were significantly higher than the non-AEP patients (median 48 [range 5-41] ppb vs. median 14 [range 10-138] ppb, P < 0.001). The cut-off value(23.5 ppb) showed that the maximum area under the ROC curve predicted AEP with a sensitivity of 0.87 and a specificity of 0.83. The post-treatment FeNO levels decreased significantly in the AEP patients, and the levels were similar to the non-AEP patients (median 19 [range 7-44] ppb vs. median 14 [range 1-58] ppb, P = 0.21) CONCLUSIONS:The FeNO level was significantly higher in AEP than non-AEP patients. FeNO measurement can be used as a diagnostic tool to differentiate AEP from non-AEP patients. |
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Authors:
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Ji Eun Lee; Chin Kook Rhee; Ji Hwan Lim; Sang Min Lee; Young Soo Shim; Choon-Taek Lee; Sei Won Lee |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: Chest Volume: - ISSN: 1931-3543 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, The Armed Forces Capital Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea1. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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