| Fractal structure of the liver: effect on drug elimination. | |
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MedLine Citation:
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PMID: 23212277 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Liver modeling in pharmacokinetics has been based on outflow curves of extracellular tracers obtained in single-pass perfused rat livers. These reference curves represent the hepatic transit time densities (TTD) of tracers. Since the fractal structure of the sinusoidal network implies a TTD with power-law tail, the question is whether the use of conventional empirical TTDs with exponential tail may lead to biased estimates of hepatic clearance. A simulation study using a novel TTD model that accounts for fractal heterogeneity of hepatic flow shows that the bias is less than about 5 %. Using this approach to determine the influence of hepatic flow dispersion on drug extraction, only a minor effect was found. The results demonstrate that there is no need for specific fractal models of hepatic drug elimination. |
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Authors:
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Michael Weiss |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-5 |
Journal Detail:
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Title: Journal of pharmacokinetics and pharmacodynamics Volume: - ISSN: 1573-8744 ISO Abbreviation: J Pharmacokinet Pharmacodyn Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096520 Medline TA: J Pharmacokinet Pharmacodyn Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand, michael.weiss@medizin.uni-halle.de. |
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