Document Detail


Fractal-dimension analysis detects cerebral changes in preterm infants with and without intrauterine growth restriction.
MedLine Citation:
PMID:  20633658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the search for a useful parameter to detect and quantify subtle brain abnormalities in infants with intrauterine growth restriction (IUGR), we hypothesised that the analysis of the structural complexity of grey matter (GM) and white matter (WM) using the fractal dimension (FD), a measurement of the topological complexity of an object, could be established as a useful tool for quantitative studies of infant brain morphology. We studied a sample of 18 singleton IUGR premature infants, (12.72 months corrected age (CA), range: 12 months-14 months), 15 preterm infants matched one-to-one for gestational age (GA) at delivery (12.6 months; range: 12 months-14 months), and 15 neonates born at term (12.4 months; range: 11 months-14 months). The neurodevelopmental outcome was assessed in all subjects at 18 months CA according to the Bayley Scale for Infant and Toddler Development - Third edition (BSID-III). For MRI acquisition and processing, the infants were scanned at 12 months CA, in a TIM TRIO 3T scanner, sleeping naturally. Images were pre-processed using the SPM5 toolbox, the GM and WM segmented under the VBM5 toolbox, and the box-counting method was applied for FD calculation of normal and skeletonized segmented images. The results showed a significant decrease of the FD of the brain GM and WM in the IUGR group when compared to the preterm or at-term controls. We also identified a significant linear tendency of both GM and WM FD from IUGR to preterm and term groups. Finally, multiple linear analyses between the FD of the GM or WM and the neurodevelopmental scales showed a significant regression of the language and motor scales with the FD of the GM. In conclusion, a decreased FD of the GM and WM in IUGR infants could be a sensitive indicator for the investigation of structural brain abnormalities in the IUGR population at 12 months of age, which can also be related to functional disorders.
Authors:
Francisco J Esteban; Nelly Padilla; Magdalena Sanz-Cortés; Juan Ruiz de Miras; Núria Bargalló; Pablo Villoslada; Eduard Gratacós
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-13
Journal Detail:
Title:  NeuroImage     Volume:  53     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1225-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Experimental Biology, University of Jaén, Jaén, Spain. festeban@ujaen.es
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MeSH Terms
Descriptor/Qualifier:
Brain / abnormalities*
Fetal Growth Retardation / pathology*
Fractals
Humans
Image Interpretation, Computer-Assisted / methods*
Infant
Infant, Newborn
Infant, Premature
Magnetic Resonance Imaging
Neuropsychological Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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