Document Detail


Fra-1 a target for cancer prevention or intervention.
MedLine Citation:
PMID:  16784822     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transcription factor activator protein-1 (AP-1) has been implicated as a driver of carcinogenesis since its original characterization. Oncogenic transcription factors like AP-1 are becoming new targets for cancer intervention. Inhibitors of AP-1 have been shown to block tumor promotion, transformation, progression and invasion. The Fos related antigen-1 (Fra-1) is activated in multiple cancers and gene ablation can suppress the invasive phenotypes of many tumor cell lines. This review focuses on the regulation of fosl1 expression, stabilization and activation of the Fra-1 polypeptide and on Fra-1-mediated tumorigenesis.
Authors:
Matthew R Young; Nancy H Colburn
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review     Date:  2006-05-06
Journal Detail:
Title:  Gene     Volume:  379     ISSN:  0378-1119     ISO Abbreviation:  Gene     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-25     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7706761     Medline TA:  Gene     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
Affiliation:
Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Frederick, MD 21702, USA. youngm@ncifcrf.gov
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transformation, Neoplastic / metabolism
Gene Expression Regulation, Neoplastic
Humans
Models, Biological
Neoplasms / drug therapy,  metabolism*,  prevention & control
Proto-Oncogene Proteins c-fos / antagonists & inhibitors,  genetics,  metabolism*
Transcription Factor AP-1 / metabolism
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Transcription Factor AP-1; 0/fos-related antigen 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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