Document Detail

Fra-1: a novel target for retinoid action.
MedLine Citation:
PMID:  10217407     Owner:  NLM     Status:  MEDLINE    
Using a cDNA gene expression array system, we identified fra-1 as a novel target molecule for retinoid action in the human pancreatic carcinoma cell line Dan-G. Retinoid treatment resulted in a significant and time-dependent induction of the fra-1 expression on the post-transcriptional level. Supershift assays revealed that fra-1 participates in the activator protein 1 complex together with c-fos, c-jun and junB. Transient transfection experiments using a reporter plasmid containing an activator protein site upstream of the CAT reporter gene revealed that the phorbolester-induced CAT activity was suppressed by retinoids. Since fra-1 lacks a transactivation function, we therefore suggest that the retinoid-mediated induction of fra-1 might function as a negative regulator of the activator protein 1 activity in human pancreatic carcinoma cells.
A Kaiser; F H Brembeck; Z v Marschall; E O Riecken; B Wiedenmann; S Rosewicz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  448     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-01     Completed Date:  1999-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  IM    
Medizinische Klinik mit Schwerpunkt Gastroenterologie/Hepatologie, Department of Gastroenterology, Klinikum Benjamin Franklin, Freie Universität Berlin, Germany.
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MeSH Terms
Gene Expression Regulation / drug effects
Proto-Oncogene Proteins c-fos / genetics*
Retinoids / metabolism*,  pharmacology
Tetradecanoylphorbol Acetate / pharmacology
Transcription Factor AP-1 / metabolism
Tretinoin / metabolism,  pharmacology
Tumor Cells, Cultured
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 0/Retinoids; 0/Transcription Factor AP-1; 0/fos-related antigen 1; 16561-29-8/Tetradecanoylphorbol Acetate; 302-79-4/Tretinoin

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