| Foxp3 expression in CD4+ T cells of patients with systemic lupus erythematosus: a comparative phenotypic analysis. | |
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MedLine Citation:
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PMID: 17728327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The forkhead family transcription factor Foxp3 currently represents the most specific marker molecule for CD4(+)CD25(+) T cells with suppressive/regulatory capacity (Treg) in the mouse. Recent studies in the human system, however, indicate that the expression of Foxp3 can be T cell activation dependent. This tempted us to evaluate the significance of Foxp3 expression under autoimmune conditions with chronic T cell activation in patients with systemic lupus erythematosus (SLE) as compared with healthy controls (HCs). METHODS: Proportions of peripheral blood CD4(+)Foxp3(+) T cells and CD4(+)CD25(high) T cells were determined in patients with active and inactive SLE as compared with HC by flow cytometry. Comparative analysis of the percentage of CD4(+)Foxp3(+) T cells and of percentage of CD4(+)CD25(high) T cells with clinical disease activity and T cell activation marker molecule expression were performed. Finally, the induction of Foxp3 expression was analysed upon T cell activation in vitro. RESULTS: Proportions of CD4(+)Foxp3(+) T cells were significantly increased in patients with SLE as compared with HC and a significant correlation was observed between clinical disease activity and proportions of CD4(+)Foxp3(+) T cells. On the other hand, proportions of CD4(+)CD25(high) were decreased in SLE and no correlation with a T cell activation marker expression of was observed. In addition, in vitro activation of T cells induced Foxp3 expression. CONCLUSIONS: Our data suggest that the expression of Foxp3 on CD4(+) T cells in patients with SLE, at least to some extent, reflects the activation of CD4(+) T cells due to underlying disease activity and does not necessarily indicate a functional regulatory T cell capacity. |
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Authors:
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M Bonelli; K von Dalwigk; A Savitskaya; J S Smolen; C Scheinecker |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-08-29 |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 67 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-04-14 Completed Date: 2008-11-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 664-71 Citation Subset: IM |
Affiliation:
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Division of Rheumatology, Internal Medicine III, Medical University of Vienna, General Hospital of Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Antigens, CD / analysis Antigens, Differentiation, T-Lymphocyte / analysis Biological Markers / analysis CD4-Positive T-Lymphocytes / chemistry* Case-Control Studies Cells, Cultured Female Flow Cytometry Forkhead Transcription Factors / analysis* Humans Interleukin-2 Receptor alpha Subunit / analysis Lupus Erythematosus, Systemic / immunology* Lymphocyte Activation Male Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, T-Lymphocyte; 0/Biological Markers; 0/CD69 antigen; 0/FOXP3 protein, human; 0/Forkhead Transcription Factors; 0/Interleukin-2 Receptor alpha Subunit |
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