Document Detail


FoxP2 Regulates Neurogenesis during Embryonic Cortical Development.
MedLine Citation:
PMID:  23283338     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The transcription factor FoxP2 has been associated with the development of human speech but the underlying cellular function of FoxP2 is still unclear. Here we provide evidence that FoxP2 regulates genesis of some intermediate progenitors and neurons in the mammalian cortex, one of the key centers for human speech. Specifically, knockdown of FoxP2 in embryonic cortical precursors inhibits neurogenesis, at least in part by inhibiting the transition from radial glial precursors to neurogenic intermediate progenitors. Moreover, overexpression of human, but not mouse, FoxP2 enhances the genesis of intermediate progenitors and neurons. In contrast, expression of a human FoxP2 mutant that causes vocalization deficits decreases neurogenesis, suggesting that in the murine system human FoxP2 acts as a gain-of-function protein, while a human FoxP2 mutant acts as a dominant-inhibitory protein. These results support the idea that FoxP2 regulates the transition from neural precursors to transit-amplifying progenitors and ultimately neurons, and shed light upon the molecular changes that might contribute to evolution of the mammalian cortex.
Authors:
David Tsui; John P Vessey; Hideaki Tomita; David R Kaplan; Freda D Miller
Related Documents :
23506838 - Neural development in eucidaris tribuloides and the evolutionary history of the echinoi...
23483698 - Transcription factor sox11 is essential for both embryonic and adult neurogenesis.
23889928 - Spindle orientation: timing is everything.
918658 - Visual association cortex and vision in man: pattern-evoked occipital potentials in a b...
24802088 - Short-term neuroplastic effects of brain-controlled and muscle-controlled electrical st...
12931188 - Trans-synaptic shift in anion gradient in spinal lamina i neurons as a mechanism of neu...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  33     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-58     Citation Subset:  IM    
Affiliation:
Programs in Developmental and Stem Cell Biology and Cell Biology, Hospital for Sick Children, Toronto, Canada M5G 1L7, and Institute for Medical Sciences and Departments of Molecular Genetics and Physiology, University of Toronto, Toronto, Canada M5G 1X5.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of digesting chondroitin sulfate proteoglycans on plasticity in cat primary visual cortex.
Next Document:  Rax is a selector gene for mediobasal hypothalamic cell types.