Document Detail

Fourth ventricular injection of CART peptide inhibits short-term sucrose intake in rats.
MedLine Citation:
PMID:  11277984     Owner:  NLM     Status:  MEDLINE    
Expression of CART (cocaine-amphetamine-regulated transcript) in the rat hypothalamus is modulated by nutritional status, and injection of synthetic CART peptide into the forebrain ventricular system suppresses food intake, indicating a possible role in hypothalamic control of energy homeostasis. Its recent identification in cell bodies and central terminals of vagal afferent neurons additionally suggests a role in brainstem mechanisms of meal termination and satiety. We demonstrate here that CART[55-102] (0.2 nmol) suppresses short-term sucrose intake and overnight chow intake in non-food-deprived rats even more when delivered into the fourth ventricle as compared to the lateral ventricle. At the threshold dose (0.02-0.08 nmol) no readily noticeable motor impairments were observed. The results are consistent, but do not prove a site of action within the brainstem, possibly in mediating vagal satiety signals at the level of the NTS.
H Zheng; C Patterson; H R Berthoud
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  896     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-30     Completed Date:  2001-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-6     Citation Subset:  IM    
Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA.
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MeSH Terms
Afferent Pathways / physiology
Brain Stem / drug effects,  physiology
Dietary Sucrose / pharmacology*
Eating / drug effects*
Fourth Ventricle
Injections, Intraventricular
Nerve Tissue Proteins / pharmacology*
Rats, Sprague-Dawley
Satiation / drug effects
Grant Support
Reg. No./Substance:
0/Dietary Sucrose; 0/Nerve Tissue Proteins; 0/cocaine- and amphetamine-regulated transcript protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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