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Fourth cranial nerve palsy and brown syndrome: two interrelated congenital cranial dysinnervation disorders?
MedLine Citation:
PMID:  23636931     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Based on neuroimaging data showing absence of the trochlear nerve, congenital superior oblique palsy is now classified as a congenital cranial dysinnervation disorder. A similar absence of the abducens nerve is accompanied by misinnervation to the lateral rectus muscle from a branch of oculomotor nerve in the Duane retraction syndrome. This similarity raises the question of whether some cases of Brown syndrome could arise from a similar synkinesis between the inferior and superior oblique muscles in the setting of congenital superior oblique palsy. This hypothesis has gained support from the confluence of evidence from a number of independent studies. Using Duane syndrome as a model, we critically review the accumulating evidence that some cases of Brown syndrome are ultimately attributable to dysgenesis of the trochlear nerve.
Authors:
Pierre-François Kaeser; Michael C Brodsky
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current neurology and neuroscience reports     Volume:  13     ISSN:  1534-6293     ISO Abbreviation:  Curr Neurol Neurosci Rep     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100931790     Medline TA:  Curr Neurol Neurosci Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352     Citation Subset:  IM    
Affiliation:
Jules Gonin Eye Hospital, University of Lausanne, Avenue de France 15, 1004, Lausanne, Switzerland, pierre-francois.kaeser@fa2.ch.
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