Document Detail

Fourier transform infrared spectra of the polypeptide alamethicin and a possible structural similarity with bacteriorhodopsin.
MedLine Citation:
PMID:  3401486     Owner:  NLM     Status:  MEDLINE    
FTIR spectra of alamethicin have been obtained in KBr disk, methanol and in aqueous lipid dispersion (above and below the lipid phase transition). The solution structure of this polypeptide in methanol has been shown by recent studies (Esposito et al. (1987) Biochemistry 26, 1043-1050) using NMR spectroscopy to be predominantly alpha-helical in content. It may therefore be regarded as a model structure for the interpretation of the spectra of certain biomembrane proteins. A comparison of the spectra with that obtained with bacteriorhodopsin shows spectral similarities, e.g. the presence of a high-frequency amide I maximum at 1661-1663 cm-1 and shoulders near 1640 cm-1 and 1620 cm-1.
P I Haris; D Chapman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  943     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-19     Completed Date:  1988-09-19     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  375-80     Citation Subset:  IM    
Department of Protein and Molecular Biology, University of London, Royal Free Hospital School of Medicine, U.K.
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MeSH Terms
Anti-Bacterial Agents*
Fourier Analysis
Magnetic Resonance Spectroscopy
Molecular Conformation
Spectrophotometry, Infrared*
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Anti-Bacterial Agents; 13699-48-4/Dimyristoylphosphatidylcholine; 27061-78-5/Alamethicin; 53026-44-1/Bacteriorhodopsins; 67-56-1/Methanol

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