Document Detail

Four years' experience with fibrin sealant in thoracic and cardiovascular surgery.
MedLine Citation:
PMID:  2369228     Owner:  NLM     Status:  MEDLINE    
A single-donor fibrin sealant system was used in 689 thoracic and cardiovascular surgical procedures over the 4-year period between April 1, 1985, and March 31, 1989. An excellent overall success rate (646/689, 94% effective) was achieved with specific applications, including reduction of leakage of air (29/33, 88% effective), blood (595/634, 94% effective), and fluid (14/14, 100% effective), as well as positioning of anatomical structures such as coronary bypass grafts (8/8, 100% effective). Application methods included use of spray bottles (477/497, 96% effective), syringes (165/186, 89% effective), and a Silastic cannula through the flexible fiber-optic bronchoscope (4/6, 67% effective). The system was used in a wide variety of cardiac, pulmonary, esophageal, and vascular procedures to seal staple lines, suture lines, anastomoses, conduits, fistulas, and raw surfaces. No complications with this single-donor system secondary to blood-borne disease have been documented. Overall infection occurred at a nominal rate (16/689, 2%). Thus, fibrin sealant has been a useful tool to control the leakage of air, blood, and fluid during a wide variety of thoracic and cardiovascular procedures and may be of benefit to other surgeons.
T L Matthew; W D Spotnitz; I L Kron; T M Daniel; C G Tribble; S P Nolan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  50     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-13     Completed Date:  1990-08-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-3; discussion 43-4     Citation Subset:  AIM; IM    
Department of Surgery, University of Virginia Health Sciences Center, Charlottesville 22908.
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MeSH Terms
Anastomosis, Surgical
Cardiac Surgical Procedures*
Coronary Artery Bypass
Fibrin Tissue Adhesive / administration & dosage,  chemical synthesis,  therapeutic use*
Heart Defects, Congenital / surgery
Heart Valve Prosthesis
Thoracic Surgery*
Reg. No./Substance:
0/Aerosols; 0/Fibrin Tissue Adhesive

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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