| Four-year incidence and progression of age-related macular degeneration: the Los Angeles Latino Eye Study. | |
| | |
MedLine Citation:
|
PMID: 20399926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE: To estimate 4-year incidence and progression of early and advanced age-related macular degeneration (AMD). DESIGN: Population-based cohort study. METHODS: A comprehensive ophthalmologic examination including stereoscopic fundus photography was performed on adult Latinos at baseline and follow-up. Photographs were graded using a modified Wisconsin Age-Related Maculopathy Grading System. For estimations of incidence and progression of AMD, the Age Related Eye Disease Study Scale was used. Main outcome measures are incidence and progression of early AMD (drusen type, drusen size, and retinal pigmentary abnormalities) and advanced AMD (exudative AMD and geographic atrophy). RESULTS: A total of 4658 of 6100 subjects (76%) completed the follow-up examination. The 4-year incidence of early AMD was 7.5% (95% CI: 6.7, 8.4) and advanced AMD was 0.2% (95% CI: 0.1, 0.4). Progression of any AMD occurred in 9.2% (95% CI: 8.3, 10.1) of at-risk participants. Incidence and progression increased with age. Incidence of early AMD in the second eye (11.2%) was higher than incidence in the first eye (6.9%). Baseline presence of soft indistinct large drusen >or=250 microm in diameter was more likely to predict the 4-year incidence of pigmentary abnormalities, geographic atrophy, and exudative AMD than smaller or hard or soft distinct drusen. CONCLUSIONS: Age-specific incidence and progression of AMD in Latinos are lower than in non-Hispanic whites. While incident early AMD is more often unilateral, the risk of its development in the second is higher than in the first eye. Older people and those with soft indistinct large drusen had a higher risk of developing advanced AMD compared to those who were younger and did not have soft indistinct large drusen. |
| | |
Authors:
|
Rohit Varma; Athena W P Foong; Mei-Ying Lai; Farzana Choudhury; Ronald Klein; Stanley P Azen; |
Related Documents
:
|
20711706 - Genetic control of complement activation in humans and age related macular degeneration. 21803286 - Dietary restriction and aging: a unifying perspective. 22874856 - Erectile dysfunction: a new plague. 9587926 - A practice-based survey of familial age-related maculopathy. 23140946 - Older age as a poor prognostic sign in patients with pyogenic liver abscess. 3647186 - Aging education in schools. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: American journal of ophthalmology Volume: 149 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-04-19 Completed Date: 2010-05-06 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
|
Languages: eng Pagination: 741-51 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Doheny Eye Institute, Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. rvarma@usc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Distribution Aged Aged, 80 and over Cohort Studies Disease Progression Female Follow-Up Studies Hispanic Americans / ethnology* Humans Incidence Los Angeles / epidemiology Macular Degeneration / classification, diagnosis, ethnology* Male Middle Aged Photography Questionnaires |
| Grant Support | |
ID/Acronym/Agency:
|
EY-03040/EY/NEI NIH HHS; U10 EY011753-02/EY/NEI NIH HHS; U10 EY011753-03/EY/NEI NIH HHS; U10 EY011753-03S1/EY/NEI NIH HHS; U10 EY011753-03S2/EY/NEI NIH HHS; U10 EY011753-03S3/EY/NEI NIH HHS; U10 EY011753-03S4/EY/NEI NIH HHS; U10 EY011753-03S5/EY/NEI NIH HHS; U10 EY011753-04/EY/NEI NIH HHS; U10 EY011753-04S1/EY/NEI NIH HHS; U10 EY011753-05/EY/NEI NIH HHS; U10 EY011753-06/EY/NEI NIH HHS; U10 EY011753-07/EY/NEI NIH HHS; U10 EY011753-07S1/EY/NEI NIH HHS; U10 EY011753-08/EY/NEI NIH HHS; U10 EY011753-08S1/EY/NEI NIH HHS; U10 EY011753-09/EY/NEI NIH HHS; U10 EY011753-10/EY/NEI NIH HHS; U10 EY011753-11A1/EY/NEI NIH HHS; U10 EY011753-12/EY/NEI NIH HHS; U10 EY011753-13/EY/NEI NIH HHS; U10-EY-11753/EY/NEI NIH HHS |
| Investigator | |
Investigator/Affiliation:
|
Rohit Varma / ; Stanley P Azen / ; Roberta McKean-Cowdin / ; Sylvia H Paz / ; Mina Torres / ; Jaime Barrera / ; Farzana Choudhury / ; Lupe Cisneros / ; Jessica Chung / ; Elizabeth Corona / ; Carolina Cuestas / ; Jeanne Dzekov / ; Athena W P Foong / ; Carlos Lastra / ; Mei-Ying Lai / ; George Martinez / ; Corina Shtir / ; Ronald E Smith / ; LaVina Tetrow / ; Ying Wang / ; Joanne Wu / ; Lisa John / ; Karen Tucker / ; Ronald Klein / ; Stacy E Meuer / ; Michael D Knutson / ; Michael Neider / |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Four-year incidence and progression of visual impairment in Latinos: the Los Angeles Latino Eye Stud...
Next Document: Association between abnormal contrast sensitivity and mortality among people with acquired immunodef...