| Four-year follow-up of poly-L-lactic Acid cages for lumbar interbody fusion in goats. | |
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MedLine Citation:
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PMID: 15777166 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: New applications of bioabsorbable polymer implants demand for histologic evaluation because a host tissue response is elicited and late complications after polymer implantation have been reported. Furthermore, in load-bearing regions an accelerated polymer degradation and foreign body reaction may be observed. METHODS: Lumbar interbody fusion procedures were performed using poly-L-lactic acid (PLLA) and titanium cages in 43 goats. At 3, 6, 12, 24, 36, and 48 months after surgery, sequential histologic analysis of instrumented motion segments, lymph nodes, and nervous structures was performed. Blood samples were retrieved for laboratory analysis. RESULTS: No adverse local or distant histologic or systemic effects were observed during the absorption of the poly-L-lactic acid cages. Interbody fusion was maintained, and only a very mild inflammatory response was observed. In half the specimens complete absorption was observed, and in the remaining specimens an estimated 1-10% of the original PLLA was present at the 3-year follow-up. At the 4-year follow-up, five out of seven PLLA specimens showed no PLLA particles under polarized light microscopy. In the remaining two specimens an estimated 1% of the original PLLA could be observed. CONCLUSIONS: Poly-L-lactic acid cages are feasible for lumbar interbody fusion, and the biocompatibility under high load bearing conditions is excellent during the complete absorption of the PLLA interbody fusion cages. |
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Authors:
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Martijn van Dijk; Paul J van Diest; Theo H Smit; Hans Berkhof; Elisabeth H Burger; Paul I J M Wuisman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of long-term effects of medical implants Volume: 15 ISSN: 1050-6934 ISO Abbreviation: J Long Term Eff Med Implants Publication Date: 2005 |
Date Detail:
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Created Date: 2005-03-21 Completed Date: 2005-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9110830 Medline TA: J Long Term Eff Med Implants Country: United States |
Other Details:
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Languages: eng Pagination: 125-38 Citation Subset: T |
Affiliation:
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Department of Orthopaedic Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorbable Implants* Animals Biocompatible Materials Bone and Bones / pathology* Drug Implants Female Follow-Up Studies Goats Lactic Acid* Lumbar Vertebrae Polymers* Spinal Fusion* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Drug Implants; 0/Polymers; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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