Document Detail

Four weeks of cycle training increases basal production of nitric oxide from the forearm.
MedLine Citation:
PMID:  9087577     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine whether nontrained vascular beds might contribute to the beneficial effects of exercise, including reduced blood pressure by enhanced nitric oxide production. Thirteen healthy, sedentary male volunteers performed 4 wk of normal sedentary activity and 4 wk of cycle training in a randomized order. At the end of each intervention, venous occlusion plethysmography was used to study the forearm blood flow responses to intra-arterial infusions of the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (L-NMMA), acetylcholine, and sodium nitroprusside. Training increased the maximal work-load and maximal oxygen consumption, whereas intrabrachial blood pressure was reduced. L-NMMA caused a greater vasoconstriction after training (P = 0.004). Net nitrate and nitrite consumption by the forearm was less after training both before and after administration of L-NMMA (P = 0.04), consistent with increased nitrate and nitrite production from nitric oxide metabolism. There was no difference in the response to acetylcholine or sodium nitroprusside between the two states. Preliminary studies showed an increase in forearm blood flow and blood viscosity after cycling, suggesting that elevated shear stress in this vascular bed may contribute to endothelial adaptation and the cardiovascular protective effects of exercise training.
B A Kingwell; B Sherrard; G L Jennings; A M Dart
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-28     Completed Date:  1997-04-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1070-7     Citation Subset:  IM    
Alfred and Baker Medical Unit, Alfred Hospital, Prahan, Victoria, Australia.
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MeSH Terms
Acetylcholine / pharmacology
Blood Pressure*
Blood Viscosity*
Cholesterol / blood
Endothelium, Vascular / drug effects,  physiology*
Exercise Test
Forearm / blood supply*
Heart Rate*
Lipoproteins, HDL / blood
Muscle, Skeletal / blood supply*
Nitric Oxide / physiology*
Nitroprusside / pharmacology
Oxygen Consumption
Reference Values
Regional Blood Flow / drug effects
Time Factors
Triglycerides / blood
omega-N-Methylarginine / pharmacology
Reg. No./Substance:
0/Lipoproteins, HDL; 0/Triglycerides; 10102-43-9/Nitric Oxide; 15078-28-1/Nitroprusside; 17035-90-4/omega-N-Methylarginine; 51-84-3/Acetylcholine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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