Document Detail

Four-way, multicenter, crossover trial of ibuprofen, fenoprofen calcium, naproxen, and tolmetin sodium in osteoarthritis: comparative clinical profiles.
MedLine Citation:
PMID:  6344227     Owner:  NLM     Status:  MEDLINE    
One hundred forty-one subjects with osteoarthritis completed this double-blind, multicenter, crossover trial comparing four nonsteroidal anti-inflammatory (NSAI) agents after single-blind aspirin stabilization. Preferences of both patients and physicians showed the following rank order from most to least preferable: tolmetin sodium, naproxen, ibuprofen, fenoprofen calcium. By all but three of more than 20 measures of efficacy, tolmetin sodium and naproxen were the more effective pair and fenoprofen calcium and ibuprofen the less effective pair of the four. Eight of nine measures of tolerability suggested the following rank order from best to worst tolerated: ibuprofen, naproxen, tolmetin sodium, fenoprofen calcium, aspirin. Few differences among the newer NSAI agents compared in this study achieved statistical significance. Nevertheless, the tolerability-efficacy relationships that emerge from studies of this type can help to define rational approaches to the use of these drugs in rheumatic diseases.
J R Caldwell; D Crain; R T Hoffmeister; F Kantrowitz; R J Lloyd; R T Nussdorf; F R Schmid; M R Repice
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  76     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-15     Completed Date:  1983-07-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  706-11     Citation Subset:  AIM; IM    
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MeSH Terms
Aspirin / therapeutic use
Clinical Trials as Topic
Double-Blind Method
Drug Tolerance
Fenoprofen / therapeutic use*
Ibuprofen / therapeutic use*
Middle Aged
Naproxen / therapeutic use*
Osteoarthritis / drug therapy*
Phenylpropionates / therapeutic use*
Pyrroles / therapeutic use*
Tolmetin / therapeutic use*
Reg. No./Substance:
0/Phenylpropionates; 0/Pyrroles; 15687-27-1/Ibuprofen; 22204-53-1/Naproxen; 26171-23-3/Tolmetin; 31879-05-7/Fenoprofen; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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