Document Detail

Four polygamous families with congenital birth defects from Fallujah, Iraq.
MedLine Citation:
PMID:  21318016     Owner:  NLM     Status:  MEDLINE    
Since 2003, congenital malformations have increased to account for 15% of all births in Fallujah, Iraq. Congenital heart defects have the highest incidence, followed by neural tube defects. Similar birth defects were reported in other populations exposed to war contaminants. While the causes of increased prevalence of birth defects are under investigation, we opted to release this communication to contribute to exploration of these issues. By using a questionnaire, containing residential history and activities that may have led to exposure to war contaminants, retrospective reproductive history of four polygamous Fallujah families were documented. Our findings point to sporadic, untargeted events, with different phenotypes in each family and increased recurrence. The prevalence of familial birth defects after 2003 highlights the relevance of epigenetic mechanisms and offers insights to focus research, with the aim of reducing further damage to people's health.
Samira Alaani; Mozhgan Savabieasfahani; Mohammad Tafash; Paola Manduca
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-31
Journal Detail:
Title:  International journal of environmental research and public health     Volume:  8     ISSN:  1660-4601     ISO Abbreviation:  Int J Environ Res Public Health     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-02-14     Completed Date:  2011-06-13     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101238455     Medline TA:  Int J Environ Res Public Health     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-96     Citation Subset:  IM    
Fallujah General Hospital, Althubbadh District, Fallujah, 00964, Iraq.
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MeSH Terms
Congenital Abnormalities / epidemiology*,  genetics
Environmental Exposure / adverse effects
Epigenesis, Genetic
Infant, Newborn
Iraq War, 2003 - 2011
Metals, Heavy / toxicity
Middle Aged
Retrospective Studies
Teratogens / toxicity
Young Adult
Reg. No./Substance:
0/Metals, Heavy; 0/Teratogens

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