Document Detail

Four patients with myelodysplastic syndrome with translocation (1;7)(p11;p11) including one patient with independent clones del(7)q22) [corrected] and t(1;7)(q21;q11)
MedLine Citation:
PMID:  3422049     Owner:  NLM     Status:  MEDLINE    
A translocation involving the short arm of chromosome #1 and the short arm of chromosome #7, [t(1;7)(p11;p11)] was present in four patients with myelodysplastic syndrome (MDS). Two of these patients had prior lymphoproliferative disorders and developed MDS following prolonged therapy with alkylating agents. One of the patients with prior therapy history has two additional independent abnormal clones: one with a partial deletion of the long arm of #7 and the other with t(1;7)(q21;q11). A third patient had a family history of leukemia in both the father and a brother, both of whom developed acute nonlymphocytic leukemia following an MDS phase. The last patient was an elderly woman with no predisposing features.
R Tantravahi; M A Shipp; T A Greeley; K Pavelka; M M Bern; D S Rosenthal; E Frei
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  30     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-02     Completed Date:  1988-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  83-90     Citation Subset:  IM    
Cytogenetics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02115.
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MeSH Terms
Chromosome Banding
Chromosome Deletion*
Chromosomes, Human, Pair 1*
Chromosomes, Human, Pair 7*
Genetic Markers
Middle Aged
Myelodysplastic Syndromes / genetics*
Translocation, Genetic*
Reg. No./Substance:
0/Genetic Markers
Erratum In:
Cancer Genet Cytogenet 1988 Feb;30(2):346

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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