| Four patients with myelodysplastic syndrome with translocation (1;7)(p11;p11) including one patient with independent clones del(7)q22) [corrected] and t(1;7)(q21;q11) | |
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MedLine Citation:
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PMID: 3422049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A translocation involving the short arm of chromosome #1 and the short arm of chromosome #7, [t(1;7)(p11;p11)] was present in four patients with myelodysplastic syndrome (MDS). Two of these patients had prior lymphoproliferative disorders and developed MDS following prolonged therapy with alkylating agents. One of the patients with prior therapy history has two additional independent abnormal clones: one with a partial deletion of the long arm of #7 and the other with t(1;7)(q21;q11). A third patient had a family history of leukemia in both the father and a brother, both of whom developed acute nonlymphocytic leukemia following an MDS phase. The last patient was an elderly woman with no predisposing features. |
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Authors:
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R Tantravahi; M A Shipp; T A Greeley; K Pavelka; M M Bern; D S Rosenthal; E Frei |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Cancer genetics and cytogenetics Volume: 30 ISSN: 0165-4608 ISO Abbreviation: Cancer Genet. Cytogenet. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-02-02 Completed Date: 1988-02-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909240 Medline TA: Cancer Genet Cytogenet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-90 Citation Subset: IM |
Affiliation:
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Cytogenetics Laboratory, Dana-Farber Cancer Institute, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chromosome Banding Chromosome Deletion* Chromosomes, Human, Pair 1* Chromosomes, Human, Pair 7* Female Genetic Markers Humans Karyotyping Male Middle Aged Myelodysplastic Syndromes / genetics* Translocation, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Genetic Markers |
| Comments/Corrections | |
Erratum In:
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Cancer Genet Cytogenet 1988 Feb;30(2):346 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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