| Four new koumine metabolites in rat liver microsomes. | |
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MedLine Citation:
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PMID: 23323600 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Four new metabolites M-1 [1,2,18,19-tetradehydro-4-demethyl-3,17-epoxy-7,20(2H,19H)-cyclovobasan], M-2 [1,2,4,21,18,19-hexadehydro-4-demethyl-3,17-epoxy-7,20(2H,19H)-cyclovobasan], M-3 [1,2,18,19-tetradehydro-4-demethyl-4-formaldehyde-3,17-epoxy-7,20(2H,19H)-cyclovobasan], and M-4 [1,2,4,21,18,19-hexadehydro-4-demethyl-4-oxy-3,17-epoxy-7,20(2H,19H)-cyclovobasan] were isolated from the chloroform extract of koumine incubated with phenobarbital-treated rat liver microsomes. The structures of M-1, M-2, M-3, and M-4 were elucidated by spectroscopic methods including ESI-TOF-MS, 1D, and 2D NMR experiments. The metabolic pathway of koumine was proposed. The cytotoxic activities between koumine and its metabolites were also compared in the A549 cell line. |
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Authors:
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Lin Zhang; Lan Du; Wen-Wen Lv; Qing-Chun Zhao; Wei Hua; Ye An; Tao Guo; Li-Jun Wu |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
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Title: Journal of Asian natural products research Volume: - ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Department of Pharmacy , General Hospital of Shenyang Military Area Command , Shenyang , 110840 , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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